Neurotrophic factors. (©1993)

• Record Type: Book
• Further Information: Note: Edited by Sandra E. Loughlin and James H. Fallon.
• Other Names: Loughlin, Sandra E; Fallon, James H
• Contents: Cover image; Title page; Table of Contents; Copyright page; Contributors; Preface; 1: Functional Implications of the Anatomical Localization of Neurotrophic Factors; I INTRODUCTION; II NEUROTROPHIC FACTORS INCLUDED IN THIS VOLUME; III REVIEW OF CELLULAR EVENTS OF NEUROTROPHIC FACTOR SYSTEMS; IV MODES OF SECRETION AND TRANSPORT OF NEUROTROPHIC FACTORS; V NEUROTROPHIC FACTOR DISTRIBUTION IN CENTRAL NEURAL SYSTEMS; VI SUMMARY; ACKNOWLEDGMENTS; 2: Neurotrophic Factors: What Are They and What Are They Doing?; I HISTORY; II DEFINITION; III PHYSIOLOGICAL FUNCTIONS OF NEUROTROPHIC FACTORS. IV PHARMACOLOGICAL EXPLOITATION OF NEUROTROPHIC FACTORSV CONCLUSIONS; 3: Synergy, Retrograde Transport, and Cell Death; I INTRODUCTION; II CELL DEATH; III AXOPLASMIC TRANSPORT; IV INTERACTIONS BETWEEN NEURONALLY ACTIVE MOLECULES; V MECHANISMS OF INTERACTION; VI OTHER MECHANISMS TO ACHIEVE A RETROGRADE MESSAGE; VII CONCLUSIONS; 4: Primary Response Gene Expression in the Nervous System; I INTRODUCTION; II fos AND jun GENES AS PROTOTYPICAL PRIMARY RESPONSE GENES; III OTHER PRIMARY RESPONSE GENES; IV IN VITRO EXPRESSION OF PRIMARY RESPONSE GENES IN NEURAL SYSTEMS. V IN VIVO EXPRESSION OF PRIMARY RESPONSE GENESVI SECONDARY RESPONSE GENES AS TARGETS OF PRIMARY RESPONSE GENES; VII SPECIFICITY OF PRIMARY RESPONSE GENE EXPRESSION; 5: Nerve Growth Factor and Related Substances: Structure and Mechanism of Action; I INTRODUCTION; II NGF STRUCTURE; III RECEPTORS; IV MECHANISM OF ACTION OF NGF; V SUMMARY AND CONCLUSIONS; ACKNOWLEDGMENTS; 6: Regulation of Nerve Growth Factor Expression; I EXPRESSION IN THE TARGET; II EXPRESSION IN NEURAL SUPPORTING CELLS AFTER INJURY; III EXPRESSION IN EARLY DEVELOPMENT AND NONNEURAL SETTINGS. IV BIOLOGIC SIGNIFICANCE OF NGF REGULATION:STRATEGIES FOR MANIPULATION IN VIVO7: Nerve Growth Factor: Actions in the Peripheral and Central Nervous Systems; I INTRODUCTION; II NGF ACTIONS IN THE PERIPHERAL NERVOUS SYSTEM; III NGF ROLE IN THE CENTRAL NERVOUS SYSTEM; 8: Brain-Derived Neurotrophic Factor: An NGF-Related Neurotrophin; I INTRODUCTION; II NGF: PROTOTYPICAL NEUROTROPHIC FACTOR; III SEARCH FOR OTHER NEUROTROPHIC FACTORS; VI DISCOVERY OF NEUROTROPHIC "ACTIVITIES" DISTINCT FROM NGF; V PURIFICATION OF BDNF FROM PORCINE BRAIN; VI NEURONAL SPECIFICITY OF BDNF. VII BDNF PREVENTS NEURONAL DEATH IN VIVOVIII MOLECULAR CLONING OF PORCINE, MOUSE, RAT, AND HUMAN BDNF; IX CONSEQUENCES OF THE MOLECULAR CLONING OF BDNF; X BINDING OF BDNF TO SPECIFIC RECEPTORS; XI NEUROTROPHIN FAMILY OF NGF-RELATED NEUROTROPHIC FACTORS-NGF, BDNF, NT-3, AND OTHERS; XII CLINICAL PERSPECTIVE; XIII CONCLUSIONS; ACKNOWLEDGMENTS; 9: Biochemistry and Molecular Biology of Fibroblast Growth Factors; I INTRODUCTION; II STRUCTURE AND EXPRESSION OF FGF GENES; III PROTEIN STRUCTURES; IV RECEPTORS; V INHIBITORS; VI SIGNAL TRANSDUCTION; VII BIOLOGIC FUNCTIONS.
• Publisher Details: San Diego : Academic Press
• Publication Date: 1993
• Copyright Date: 1993
• Extent: 1 online resource (xxi, 607 pages), illustrations (some color)
• Subjects: 591.1/88; Neurotrophic functions; Growth factors; Nerve Growth Factors -- physiology; SCIENCE -- Life Sciences -- Zoology -- General; Growth factors; Neurotrophic functions; Sistema nervoso central; Tecido nervoso; Nervenwachstumsfaktor; Neurotropher Faktor; Electronic books
• Languages: English
• ISBNs: 9780080571324; 0080571328
• Related ISBNs: 0124558305; 9780124558304
• Notes: Note: Includes bibliographical references and index.; Note: Print version record.
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.