Blood substitutes. (2005)

• Record Type: Book
• Further Information: Note: Edited by Robert M. Winslow.
• Other Names: Winslow, Robert M, 1941-
• Contents: BACKGROUND ; Historical Background; Transfusion Medicine; Regulatory Perspectives on Clinical Trials for Oxygen Therapeutics in Trauma and Transfusion Practice; PHYSIOLOGICAL BASIS ; Clinical Physiology: Oxygen Transport and the Transfusion Trigger; The Role of Oxygen and Hemoglobin Diffusion in Oxygen Transport by Cell-Free Hemoglobins; Oxygen Transport Properties of Hemoglobin- Based Oxygen Carriers: Studies Using Artificial Capillaries and Mathematical Stimulation; Mechanisms of O2 Transport in the Microcirculation: Effects of Cell-Free O2 Carriers; Shear Stress, Mechanotransduction and the Flow Properties of Blood; Local Regulation of Blood Flow; CLINICAL APPLICATIONS ; Clinical Indications for Blood Substitutes and Optimal Properties; Crystalloid Solutions; Hemoglobin-Based Oxygen Carriers as Resuscitative Solutions for Trauma and Combat Casualty Care; Surgical Hemorrhage; Clinical Trials in Cardiac Surgery; Hemodilution; Clinical Hemodilution; Potential for Blood Substitutes in Tissue Ischemia; TOXICITY AND SIDE EFFECTS ; Redox and Radical Reactions of Hemoglobin Solutions: Toxicities and Protective Strategies; Pro-oxidant Activity of Hemoglobin and Endothelial Cytotoxicity; Renal Toxicity; Hemoglobin and Neurotoxicity; The Role of Inflammation in the Toxicity of Hemoglobin-based Oxygen Carriers; Hemoglobin-Induced Myocardial Lesions; PERFLUOROCARBON-BASED OXYGEN CARRIERS ; Fluorocarbon Emulsions As In Vivo Oxygen Delivery Systems: Background And Chemistry; Fluosol: The First Commercial Injectable Perfluorocarbon Oxygen Carrier; Perftoran; Rational Development of Oxyfluor™; Oxygent™, a Perfluorochemical-Based Oxygen Therapeutic for Surgical Patients; HEMOGLOBIN-BASED OXYGEN CARRIERS ; The Structural and Functional Properties of Hemoglobin and their Relevance for a Hemoglobin-based Blood Substitute; Hemoglobin Modification; Designing Recombinant Hemoglobin for Use as a Blood Substitute; Design, Conformational, Functional, and Physiological Characterization of Recombinant Polymeric Heme-Proteins; áá-Crosslinked Hb; DCLHb and rHb1.1; Studies with DCLHb; Hemopure® [Hboc-201, Hemoglobin Glutamer-250 (Bovine)]: Preclinical Studies; Hboc-201, [Hemoglobin Glutamer-250 (Bovine), Hemopure®]: Clinical Studies; Polyhemoglobin-Enzymes as New Generation Blood Substitutes and Oxygen Therapeutics; Surface Decoration of Hemoglobin with Polyethylene Glycol; Hemospan™ (MP4), a Human Hemoglobin Modified with Maleimide-Polyethylene Glycol; Dextran-Hemoglobin; Development of Non-extravasating, Hemoglobin-Based Oxygen Carriers; LIPOSOMES AND RELATED PRODUCTS ; Liposome Encapsulated Hemoglobin: History, Preparation, and Evaluation; Hemoglobin-Vesicles as a Molecular Assembly:Characteristics of Preparation Process and Performances as Artificial Oxygen Carriers; Nanodimension Biodegradable Polymeric Membrane Artificial Red Blood Cells; Albumin-Heme: A Synthetic Heme-Based Oxygen Carrier; GLOSSARY ; INDEX
• Publisher Details: Place of publication not identified : Academic Press
• Publication Date: 2005
• Extent: 1 online resource (576 pages)
• Subjects: 615/.399; Blood substitutes
• Languages: English
• ISBNs: 9780080454146; 0080454143
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.