Exposure-response modeling : methods and practical implementation /: methods and practical implementation. (2015)

• Record Type: Book
• Further Information: Note: Jixian Wang.
• Authors: Wang, Jixian
• Contents: Introduction; Multifaceted exposure-response relationships; Practical scenarios in ER modeling; Models and modeling in exposure-response analysis; Model-based decision-making and drug development; Drug regulatory guidance for analysis of exposure-response relationship; Examples and modeling software Basic exposure and exposure-response models; Models based on pharmacological mechanisms; Statistical models; Transformations; Semiparametric and nonparametric models; Comments and bibliographic notes Dose-exposure and exposure-response models for longitudinal data; Linear mixed models for exposure-response relationships; Modeling exposures with linear mixed models; Nonlinear mixed ER models; Modeling exposure with a population PK model; Mixed effect models specified by differential equations; Generalized linear mixed model and generalized estimating equation; Generalized nonlinear mixed models; Testing variance components in mixed models ; Nonparametric and semiparametric models with random effects; On distributions of random effects; Bibliographic notes Sequential and simultaneous exposure-response modeling; Joint models for exposure and response; Simultaneous modeling of exposure and response models; Sequential exposure-response modeling; Measurement error models and regression calibration; Instrumental variable methods; Modeling multiple exposure and response; Internal validation data and partially observed and surrogate exposure measures; Comments and bibliographic notes Exposure-risk modeling for time-to-event data; An example; Basic concepts and models for time-to-event data; Dynamic exposure model as a time varying covariate; Multiple TTE and competing risks; Models for recurrent events; Frailty: Random effects in TTE models; Joint modeling of exposure and time to event; Interval censored data; Model identification and misspecification; Random sample simulation from exposure-risk models; Comments and bibliographic notes Modeling dynamic exposure-response relationships; Effect compartment models; Indirect response models; Disease process models; Fitting dynamic models for longitudinal data; Semiparametric and nonparametric approaches; Dynamic linear and generalized linear models; Testing hysteresis; Comments and bibliographic notes Bayesian modeling and model-based decision analysis; Bayesian modeling; Bayesian decision analysis; Decisions under uncertainty and with multiple objectives; Evidence synthesis and mixed treatment comparison; Comments and bibliographic notes Confounding bias and causal inference in exposure-response modeling; Introduction; Confounding factors and confounding biases; Causal effect and counterfactuals; Classical adjustment methods; Directional acyclic graphs; Bias assessment; Instrumental variable; Joint modeling of exposure and response; Study designs robust to confounding bias or allowing the use of instrument variables; Doubly robust estimates; Comments and bibliographic notes Dose-response relationship, dose determination, and adjustment; Marginal dose-response relationships; Dose-response relationship as a combination of dose-exposure and exposure-response relationships; Dose determination: Dose-response or dose-exposure-response modeling approaches?; Dose adjustment; Dose adjustment and causal effect estimation; Sequential decision analysis; Dose determination: Design issues; Comments and bibliographic notes Implementation using software; Two key elements: Model and data; Linear mixed and generalized linear mixed models; Nonlinear mixed models; A very quick guide to NONMEM Appendix Bibliography Index
• Edition: 1st
• Publisher Details: Boca Raton : Chapman & Hall/CRC
• Publication Date: 2015
• Extent: 1 online resource, illustrations (black and white)
• Subjects: 615.19015118; Drugs -- Dose-response relationship -- Mathematical models; Drug development -- Mathematical models
• Languages: English
• ISBNs: 9781466573215
• Related ISBNs: 9781466573208
• Notes: Note: Description based on CIP data; item not viewed.
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.