Introductory adaptive trial designs : a practical guide with R /: a practical guide with R. (2015)

• Record Type: Book
• Further Information: Note: Mark Chang.
• Authors: Chang, Mark
• Contents: Introduction; Motivation; Adaptive Designs in Clinical Trials; Clinical Trial Simulation; Characteristics of Adaptive Designs; FAQs about Adaptive Designs Classical Design ; Introduction; Two-Group Superiority; Two-Group Noninferiority Trial; Two-Group Equivalence Trial; Trial with Any Number of Groups; Multigroup Dose-Finding Trial; Summary and Discussion Two-Stage Adaptive Confirmatory Design Method ; General Formulation; Method Based on Sum of p -Values; Method with Product of p -Values; Method with Inverse-Normal p -Values; Comparisons of Adaptive Design Methods K -Stage Adaptive Confirmatory Design Methods ; Test Statistics; Determination of Stopping Boundary; Error-Spending Function; Power and Sample Size; Error Spending Approach Sample-Size Reestimation Design ; Sample Size Reestimation Methods; Comparisons of SSR Methods; K -Stage Sample Size Reestimaion Trial; Summary Special Two-Stage Group Sequential Trials ; Event-Based Design; Equivalence Trial; Adaptive Design with Farrington-Manning Margin; Noninferiority Trial with Paired Binary Data; Trial with Incomplete Paired Data; Trial with Coprimary Endpoints; Trial with Multiple Endpoints Pick-the-Winners Design; Overview of Multiple-Arm Designs; Pick-the-Winner Design; Stopping Boundary and Sample Size; Summary and Discussion The Add-Arms Design ; Introduction; The Add-Arm Design; Clinical Trial Examples; Extension of Add-Arms Designs; Summary Biomarker-Adaptive Design ; Taxonomy; Biomarker-Enrichment Design; Biomarker-Informed Adaptive Design; Summary Response-Adaptive Randomization ; Basic Response-Adaptive Randomizations; Generalized Response-Adaptive Randomization; Summary and Discussion Adaptive Dose-Escalation Trial ; Oncology Dose-Escalation Trial; Continual Reassessment Method; Alternative Form CRM; Evaluation of Dose-Escalation Design; Summary and Discussion Deciding Which Adaptive Design to Use; Determining the Objectives; Determining Design Parameters; Evaluation Matrix of Adaptive Design Monitoring Trials and Making Adaptations; Stopping and Arm-Selection; Conditional Power; Sample-Size Reestimation; New Randomization Scheme Data Analyses of Adaptive Trials ; Orderings in Sample Space; Adjusted p -Value; Parameter Estimation; Confidence Interval; Summary Planning and Execution ; Study Planning; Working with a Regulatory Agency; Trial Execution; Summary Appendix A: Thirty-Minute Tutorial to R; Appendix B: R Functions for Adaptive Designs Bibliography Index
• Edition: 1st
• Publisher Details: Boca Raton : Chapman & Hall/CRC
• Publication Date: 2015
• Extent: 1 online resource, illustrations (black and white)
• Subjects: 615.50724; Clinical trials -- Design -- Statistical methods; Adaptive sampling (Statistics); R (Computer program language)
• Languages: English
• ISBNs: 9781498717472
• Related ISBNs: 9781498717465
• Notes: Note: Description based on CIP data; item not viewed.
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