Immune system modelling and simulation. (2015)

• Record Type: Book
• Further Information: Note: Filippo Castiglione, Franco Celada.
• Authors: Castiglione, Filippo, 1969-; Celada, Franco
• Contents: Immunology for aliens Leo Szilard paradox: Grand Central Terminal Non-specific defense Levels of evolution How is a trait selected if it was not needed? Luck or foresight? Blood brothers The members of the winning team are rewarded Somatic recombination produces diversity among equals The workshop of the adaptive response Repertoires A battalion of one Self-inflicted damage threatens survival Don’t think, but reason and understand Full cover comes at a cost A bet, not a fantasy, about earliest happenings The cooperation of very different cells multiplies jobs that can be done Thymus deeds Hypothesis is a bet: Tips for the Aliens To grow and to change Philosophy storm Suicide In the beginning The linear transmission of activation Recipe for complete Freund have them An antibody is an antibody (or two?) Scientific Myths: God's mess with human cognition A monument to interdisciplinarity Scientific Myths 2: Apollo roams about the hills of Tennessee Plain reasoning breaks the Spell Of wolfs, dogs and shepherds How to block anti-self Controlling self- damage needs structures: the lymphoid organs Time of strengthening Maturity A cognitive system? A floating brain? Cellular Automaton makes sense Memory is in the numbers The power rests with whoever issues regulatory signals The seed is prepared during the primary response The challenge Competition in the minefield of cross reactions The compensated immune system wants to understand The two immune systems The cellular branch confronts a virus infection How to model the cellular and the humoral together Body and soul, actions and philosophy What steps can and should be simulated Attrition and cross-reaction Memory is strong, sometimes too strong IMMSIM reveals MaN (Memory anti Naïve) as a cause of aging A course leading to aging of the immune system A new challenge for modelers: conformation Protein Conformation and the immune system Antibody mediated activation of a mutant enzyme More fields for models, and where to find them A note to encourage cross referencing An unconventional glossary for aliens Aliens for immunology The unusual mix of immunology and computer science Classical modeling techniques versus the "new kind of science" From spin-like to agent-based models The ancestors The others C-ImmSim unveiled Model compartments The cells The molecules The repertoire The molecular affinity Reshaping the affinity landscape Haematopoiesis and cell homeostasis The selection of cells in the thymus The Hayflick limit Cell aging and death A (dynamic) immune memory The hyper-mutation of antibodies Immune activation Anergy Interactions among entities Antigen digestion and presentation Cell motion and diffusion of molecules Main procedures Notes on the expressed repertoire Scaling the system size Few words on the definition of molecular quanta The choice of the MHC molecules The parameters What to monitor? Benchmarks aka qualitative model validation Primary and secondary response Exhaustion Bacterial Infection Viral infection Modelling idiotypes and the idiotype network Specific applications A multi-scale approach to model hypersensitivity HIV infection and AIDS Immunodominance in cancer immunotherapies Embedding immunoinformatics predictions One last word Bibliography
• Edition: 1st
• Publisher Details: Boca Raton : CRC Press
• Publication Date: 2015
• Extent: 1 online resource, illustrations (black and white)
• Subjects: 616.0790113; Immune system -- Computer simulation
• Languages: English
• ISBNs: 9781466597495
• Related ISBNs: 9781466597488
• Notes: Note: Includes bibliographical references and index.; Note: Description based on CIP data; item not viewed.
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.