Design and analysis of clinical trials for predictive medicine. (2015)

• Record Type: Book
• Further Information: Note: Edited by Shigeyuki Matsui, Marc Buyse, Richard Simon.
• Editors: Matsui, Shigeyuki; Buyse, Marc E; Simon, Richard M, 1943-
• Contents: INTRODUCTORY OVERVIEW; Clinical Trials for Predictive Medicine: New Paradigms and Challenges ; Richard Simon, Shigeyuki Matsui, and Marc Buyse ; ; An Industry Statistician’s Perspective on Personalized Health Care Drug Development ; Jane Fridlyand, Ru-Fang Yeh, Howard Mackey, Thomas Bengtsson, Paul Delmar, Greg Spaniolo, and Grazyna Lieberman ; ; Analytical Validation of In Vitro Diagnostic Tests ; Robert Becker, Jr. ; ; EARLY CLINICAL TRIALS USING BIOMARKERS ; Phase I Dose-Finding Designs and Their Applicability to Targeted Therapies ; Takashi Daimon, Akihiro Hirakawa, and Shigeyuki Matsui ; ; An Overview of Phase II Clinical Trial Designs with Biomarkers ; Lisa McShane and Sally Hunsberger ; ; Bayesian Adaptive Methods for Clinical Trials of Targeted Agents ; Peter Thall ; ; Outcome-Adaptive Randomization in Early Clinical Trials ; Edward Korn and Boris Freidlin ; ; Challenges of Using Predictive Biomarkers in Clinical Trials ; Sumithra Mandrekar and Daniel Sargent ; ; PHASE III RANDOMIZED CLINICAL TRIALS USING BIOMARKERS ; Comparison of Randomized Clinical Trial Designs for Targeted Agents ; Antje Hoering, Mike LeBlanc, and John Crowley ; ; Phase III All-Comers Clinical Trials with a Predictive Biomarker ; Shigeyuki Matsui, Yuki Choai, and Takahiro Nonaka ; ; Evaluation of Clinical Utility and Validation of Gene Signatures in Clinical Trials ; Stefan Michiels and Federico Rotolo ; ; ANALYSIS OF HIGH-DIMENSIONAL DATA AND GENOMIC SIGNATURE DEVELOPMENTS ; Statistical Issues in Clinical Development and Validation of Genomic Signatures ; Shigeyuki Matsui ; ; Univariate Analysis for Gene Screening: Beyond Multiple Testing ; Hisashi Noma and Shigeyuki Matsui ; ; Statistical and Machine-Learning Methods for Class Prediction in High Dimension ; Osamu Komori and Shinto Eguchi ; ; Survival Risk Prediction Using High-Dimensional Molecular Data ; Harald Binder, Thomas Gerds, and Martin Schumacher ; ; RANDOMIZED TRIALS WITH BIOMARKER DEVELOPMENT AND VALIDATION ; Adaptive Clinical Trial Designs with Biomarker Development and Validation ; Boris Freidlin and Richard Simon ; ; Development and Validation of Continuous Genomic Signatures in Randomized Clinical Trials ; Shigeyuki Matsui ; ; EVALUATION OF SURROGATE BIOMARKERS ; Biomarker-Based Surrogate Endpoints ; Marc Buyse, Tomasz Burzykowski, Geert Molenberghs, and Ariel Alonso
• Edition: 1st
• Publisher Details: Boca Raton : Chapman & Hall/CRC
• Publication Date: 2015
• Extent: 1 online resource, illustrations (black and white)
• Subjects: 610.724; Clinical trials -- Statistical methods; Prognosis; Molecular diagnosis
• Languages: English
• ISBNs: 9781466558168
• Related ISBNs: 9781466558151
• Notes: Note: Description based on CIP data; item not viewed.
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.