General and molecular pharmacology : principles of drug action /: principles of drug action. (2015)

• Record Type: Book
• Further Information: Note: Edited by Francesco Clementi, Guido Fumagalli.
• Editors: Clementi, Francesco; Fumagalli, Guido
• Contents: SECTION 1-INTRODUCTION TO PHARMACOLOGY 1 Essential lexicon of pharmacology; F. Clementi and G. Fumagallli The social impact of pharmacology Essential lexicon 1.1 Alternative or non-conventional therapies 1.2 The placebo 2 A short history of pharmacology; V. Sironi Birth and historical developments of pharmacology Modern pharmacology The biotechnology era and the pharmacology in the third millennium 2.1 The drugs of the ancients 2.2 Ehrlich’s chemotherapy: receptor theory and clinical experimentation 2.3 The thalidomide case SECTION 2 GETTING THE DRUG TO ITS SITE OF ACTION 3 Cellular basis of pharmacokinetics; R. Fesce and G. Fumagalli A quick journey with a drug in the body Crossing cell membranes Drug diffusion across membranes and the Fick’s law Drug diffusion to organs and tissues Properties of the most important cell barriers 3.1 Pharmacokinetics 4 Drug absorption and administration routes; R. Fesc and, G. Fumagalli General rules about drug absorption rate Enteral routes of administration Systemic parenteral routes of administration Other routes of drug administration Absorption kinetics Drug delivery: formulations to control absorption and release site 5 Drug distribution and elimination; R. Fesce and G. Fumagalli Distribution Elimination Renal excretion of drugs Hepatic excretion and entero-hepatic cycle 6 Drug metabolism; E. Chiesara, L. Marabini and S.Radice Metabolic modification of drug activity Two phases of drug metabolism Phase I reactions Phase II enzymatic reaction Extrahepatic biotransformations Pharmaco-metabolic induction and inhibition 6.1 Factors that modify drug metabolism 6.2 Induction of drug metabolism 6.3 Modulations of efficacy due to interactions between synthetic and herbal drugs 7 Control of drug plasma concentration; R. Fesce and G. Fumagalli Time course of plasma drug concentration following a single administration Drugs distribute to organs and tissues and then are eliminated Drug plasma concentration time course during ripetitive administration Multi compartmental kinetics Corrections of the therapeutic regimen 7.1 Therapeutic drug monitoring 7.2 The distribution of drugs administered by inhalation SECTION 3 RECEPTORS AND SIGNAL TRANSDUCTION 8 Drug-receptor interactions: quantitative and qualitative aspects; G. Rovati and V. Capra General properties of drug receptors Chraracteristics of drug-receptor interactions Quantitative aspects of drug effects: dose-response curves From drug-receptor interaction to drug response 8.1 Methods for receptor investigations 8.2 Receptor binding assays 9 Receptors and modulation of their response; F. Clementi and G. Fumagalli Classes of receptor and strategies of signal transduction Control of receptor localisation in the cell membrane Intracellular traffic of cell receptors Modulation of receptor responses Receptor modulation by drugs 9.1 Birth and evolution of receptor’s theories 9.2 Regulation of the receptor response 9.3 Intracellular trafficking of receptors 10 Adaptation to drug response and drug dependence; C. Chiamulera Molecular, cellular and systemic adaptation Drug addiction as a paradigm of allostatic adaptation Therapy for drug dependence 10.1 Types of memory 10.2 A modern definition of memory 10.3 Conditioning as the core od addictive behavior 10.4 Visualization techniques 11 Pharmacological modulation of post-translational modifications; M. Di Luca, F. Valtorta and F. Gardoni Protein phosphorilation SUMOylation Ubiquitination Glycosylation Acetylation Hydroxylation Carboxylation Methylation S-nitrosylation Disulfide bonds Lipids modifications Pharmacological control of post-translational modifications 12 Calcium homeostasis within the cells; J. Meldolesi and G.Fumagalli The cytosol, a crossroad of Ca2+ fluxes The plasma membrane: channels, pumps and transporters Ca2+ in the intracellular organelles Ca2+ in cell pathology 12.1 Cytosolic proteins that bind Ca2+ with high affinity 12.2 Surface Ca2+ channels: TRP, ORAI, SOCC channels and their functions 12.3 Ca2+ pumps of plasma membrane and intracellular rapidly exchanging Ca2+ stores 12.4 Ca2+ binding proteins of the ER lumen 12.5 ER channels: Ip3 and Ryanodine receptors 12.6 Local Ca2+ spikes can evolve into oscillations and waves 12.7 Mitochondria: semiautonomous organelles that need ER to operate 12.8 The nucleus is also operative in Ca2+ homeostasis 13 Pharmacology of MAP Kinases; L. Vicentini and M. G. Cattaneo The MAPK family and the activation mechanism MAPK specificity Pharmacological inhibition of MAPK 13.1 Phosphatases with dual specificity as regulators of MAPK activity 13.2 Role of MAPKs in memory and learning 13.3 ERK activation by G protein-coupled receptors 14 Small G Proteins; E. Ligeti and T. Wieland Structure and funtion of SMGs Physiological role of major SGG families Posttranslational modifications and subcellular localizationsì of SMGs Regulatory proteins Modulation of small G-protein signaling by bacterial toxins and drugs Future perspectives 15 Integration in intracellular transduction of receptor signals; Jacopo Meldolesi Dualism of receptors in the nucleus and in the cytoplasm Heterogeneity of receptor assembly Transduction cascades depend on cross-talk and complementarity among receptors Development of new drugs and therapies 15.1 Neurotrophins 15.2 Wnt and Hedgehog signaling pathways: two future drug targets? SECTION 4 RECEPTOR CLASSES 16 Ligand gated ion channels; C. Gotti and F. Clementi Tissue distribution and subcellular localization of LGICs Molecular organisation of LGICs Topology of LGICs Modulation of LGICs Cross talk with other receptor systems Mechanisms of action of drugs that modulate LGICs 16.1 Evolution of ligand gated ion channels 16.2 How to identify the amino acids that make up the inner wall of LGICs 17 G-protein coupled receptors; L. Vallar, M.P. Abbracchio and L. Vicentini, Molecular organisation of GPCRs Molecular organization and function of G protein Effectors pathways of GPCRs Interactions of GPCRs with other proteins 17.1 Orphan receptors 17.2 Structure and conformation modifications of GPCRs 17.3 Drugs active on phosphodiesterases 18 Growth factor receptors; S. Giordano, C. Boccaccio and P. M. Comoglio Molecular structure of growth factors receptors Receptor activat
• Edition: 1st
• Publisher Details: Hoboken : John Wiley & Sons
• Publication Date: 2015
• Extent: 1 online resource
• Subjects: 615.1; Pharmacology; Molecular pharmacology
• Languages: English
• ISBNs: 9781118768686; 9781118768594
• Related ISBNs: 9781118768570
• Notes: Note: Description based on CIP data; item not viewed.
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.