Adaptive design theory and implementation using SAS and R. (2014)

• Record Type: Book
• Further Information: Note: Mark Chang.
• Authors: Chang, Mark
• Contents: Introduction; Classic Design; Theory of Hypothesis-Based Adaptive Design; Method with Direct Combination of P-values; Method with Inverse-Normal P-values; Adaptive Non-Inferiority Design With Paired Binary Data; Trial Design and Analysis with Incomplete Paired Data; Implementation of N-Stage Adaptive Designs; Conditional Error Function Method and Conditional Power; Recursive Adaptive Design; Unblinded Sample-Size Re-Estimation Design; Blinded Sample Size Re-Estimation; Adaptive Design with Co-Primary Endpoint; Multiple-Endpoint Adaptive Design; Pick-the-Winners Design; The Add-Arms Design For Unimodal Response; Biomarker-Adaptive Design; Biomarker-Informed Adaptive Design; Survival Modeling and Adaptive Treatment Switching; Response-Adaptive Allocation Design; Bayesian Adaptive Dose Finding Design; Bayesian Phase I-II Adaptive Design; Adaptive Design for Biosimilarity Trial; Multi-Regional Adaptive Trial Design; Bayesian Adaptive Design; Planning, Execution, Analysis, and Reporting; Data Analysis of Adaptive Design; Debates in Adaptive Designs; SAS Adaptive Design Modules: SEQDESIGN Procedure; Appendix A: Random Number Generation; Appendix B: A Useful Utility; Appendix C: SAS Macros for Add-Arm Designs; Appendix D: Implementing Adaptive Designs in R Bibliography Index
• Edition: Second edition
• Publisher Details: Boca Raton : Chapman & Hall/CRC
• Publication Date: 2014
• Extent: 1 online resource, illustrations (black and white)
• Subjects: 610.724; Clinical trials -- Design; Clinical trials -- Computer simulation; Clinical trials -- Statistical methods; Adaptive sampling (Statistics); R (Computer program language)
• Languages: English
• ISBNs: 9781482256604
• Related ISBNs: 9781482256598
• Notes: Note: Includes bibliographical references and index.; Note: Description based on CIP data; item not viewed.
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.