Neurodegenerative disease and micronutrients : prevention and treatment /: prevention and treatment. (2014)

• Record Type: Book
• Further Information: Note: Kedar N. Prasad.
• Authors: Prasad, Kedar N
• Contents: Evolution, Sources, and Functions of Antioxidant Systems; Introduction; Evolution of Antioxidant Systems Antioxidant Systems; Antioxidant Systems; Brief History of Discovery of Some Micronutrients; Sources and Forms of Vitamins; Solubility of Antioxidants and Polyphenols; Distribution of Antioxidants in the Body; Storing of Antioxidants; Can Antioxidants Be Destroyed during Cooking?; Absorption of Antioxidant and Its Significance; Functions of Individual Antioxidants; Current Controversies about Antioxidants in Prevention of Chronic Diseases; Antioxidant Defense Systems; Known Functions of Antioxidants and Polyphenolic Compounds; Conclusions; ; Oxidative Stress and Inflammation: Their Reduction by Micronutrients; Introduction; Oxidative Stress; Oxidation and Reduction Processes; How to Reduce Oxidative Stress Optimally; Factors Regulating Response of Nrf2; Differential Response of Nrf2 to ROS Stimulation during Acute and Chronic Oxidative Stress; Interpretation of Inhibition of Exercise-Induced Nrf2 Activation by Individual Antioxidant; NAC-Effects on Murine Alveolar Cells in Culture; Activation of Nrf2 by Diet Restriction; Inflammation; Types of Inflammation; Products of Inflammatory Reactions; How to Reduce Chronic Inflammation Optimally; Conclusions; ; Etiology of Alzheimer’s Disease: Prevention and Improved Management by Micronutrients; Introduction; Prevalence, Incidence, and Cost of AD; Cost of Health and Long-Term Care Services; Types of Dementia; Neuropathology of AD; Causes of AD; External Risk Factors for the Development of AD; Internal Risk Factors for Development and Progression of AD; Mitochondrial Dysfunction; Generation and Aggregation of Aβ1–42 Peptides from APP; Cholesterol-Induced Generation of Beta-Amyloids; Mutated APP, Presenilin-1, and Presenilin-2 Genes Cause Increased Production of Beta-Amyloids; Increased Levels of Markers of Chronic Inflammation in AD; P-Tau Protein in AD; Proteasome Inhibition-Induced Neurodegeneration in AD; Genetic Defects in Idiopathic AD; Neuroglobin; How to Reduce Oxidative Stress Optimally; Differential Response of Nrf2 to ROS Stimulation during Acute and; Chronic Oxidative Stress; Nrf2 in AD; Laboratory and Clinical Studies with Antioxidants in AD; B Vitamins; Polyphenolic Compounds; Prevention of AD; Problems of Using a Single Nutrient in AD; Rationale for Using Multiple Micronutrients in AD; Rational for Using Low-Dose NSAID in AD Prevention; Can the Familial AD Be Prevented or Delayed?; Recommended Micronutrients in Combination with Low-Doses of; NSAID for Primary Prevention of AD; Recommended Micronutrients in Combination with Low-Doses of; NSAID for Secondary Prevention; Current Treatments of AD; Recommended Micronutrients and Low Dose of NSAID in Combination with; Standard Therapy in Patients with Dementia with or without AD; Diet and Lifestyle Recommendations for AD; Conclusions; ; ; Etiology of Parkinson’s Disease: Prevention and Improved Management by Micronutrients; Introduction; Prevalence and Incidence; Cost; Neuropathology and Symptoms; Causes of PD; External Factors That Influence Risk of Developing PD; Internal Factors Influencing Development and Progression of PD; Increased Oxidative Stress in PD; Mitochondrial Dysfunction in PD; Increased Chronic Inflammation in PD; Mutations or Overexpression in PD-Related Genes; DJ-1 Gene; Alpha-Synuclein Gene; PTEN-Induced Putative Kinase 1 Gene; Parkin Gene; Mutation in Lysosomal Gene SMPD1; Proteomic Profiling of Substantia Nigra in PD; How to Reduce Oxidative Stress Optimally; Differential Response of Nrf2 to ROS Stimulation during Acute and Chronic Oxidative Stress; Nrf2 in Parkinson’s Disease; Laboratory and Human Studies in PD after Treatment with; Antioxidants and Polyphenolic Compounds; Studies on In Vitro PD Models; Studies on Human PD; NAD/NADH; Prevention of PD; Problems of Using Single Antioxidant in PD Patients; Rationale for Using Multiple Micronutrients in PD; Rationale for Using NSAID in PD Prevention; Can the Familial PD Be Prevented or Delayed?; Recommended Micronutrient Supplement in Combination with; Low Doses of NSAID for Primary Prevention of PD; Recommended Micronutrients in Combination with Low Doses of; NSAID for Secondary Prevention; Treatments of PD; Rationale for Using Micronutrient Supplement and NSAID in; Combination with Standard Therapy in PD Patients; Recommended Micronutrient Supplement and Low Doses of NSAID in; Combination with Standard Therapy in PD Patients; Diet and Lifestyle Recommendations for PD; Conclusions; ; ; Huntington’s Disease: Prevention and Improved Management by Micronutrients; Introduction; Incidence, Prevalence, and Cost; Huntington Gene; Symptoms and Neuropathology of HD; Animal Models of HD; Increased Oxidative Stress in HD; Mitochondrial Dysfunction in HD; Increased Chronic Inflammation in HD; Glutamate-Induced Neurotoxicity in HD; Glutamate Transporter Proteins in HD; Neurotransmitter Receptors; Kynurenine Pathway in HD; Protection by Growth Factors in HD; Transcriptional Deregulation in HD; Calretinin Protein Protects Neurons in HD; Reduced Acetylcholine Release in HD; How to Reduce Oxidative Stress Optimally; Differential Response of Nrf2 to ROS Stimulation during Acute and Chronic Oxidative Stress; Nrf2 in HD; Laboratory and Clinical Studies on Antioxidants and Polyphenolic Compounds; Problems of Using a Single Antioxidant in HD Patients; Rationale for Using Multiple Antioxidants in a Micronutrient Preparation; Can the HD Be Prevented or Delayed?; Prevention and/or Delaying the Onset of HD; Proposed Prevention and/or Delaying Strategies for the Onset of HD; Current Treatments of HD; Medications for Psychiatric Disorders; Clinical Studies with Additional Drugs in HD; Recommended Micronutrients in Combination with Standard Therapy; Recommendations for Diet and Lifestyle Changes; Conclusions; References; ; Etiology of Post-traumatic Stress Disorders: Prevention and Improved Management by Micronutrients; Introduction; Prevalence, Incidence, and Cost of PTSD; Neuropathology; Major Biochemical Events; How to Reduce Oxidative Stress, Chronic Inflammation, and Glutamate Release; Differential Response of Nrf2 to ROS Generated during Acute and Chronic Oxidative Stress; Nrf2 in PTSD; Activation of Nrf2 by Diet Restriction; Studies on Antioxidants in PTSD; Proposed PTSD Prevention Studies; Problems of Using Single Micronutrient in PTSD; Rationale for Using Multiple Micronutrients in PTSD Prevention; Proposed Micronutrients for Primary PTSD Prevention; Toxicity of Ingredients in Proposed Micronutrient Preparation; Proposed Micronutrients for Secondary Prevention in High-Risk Populations; Current Standard Therapy for PTSD; Recommended Micronutrients in Combination with Standard Therapy in PTSD; Diet and Lifestyle Recommendations for PTSD; Conclusions; ; Traumatic Brain Injury: Improved Management by Micronutrients; Introduction; Incidence and Cost of TBI; Causes of Severe TBI; Symptoms; Neuropathology; Scoring System of Severity of TBI; Risk of PTSD Associated with TBI; Biochemical Events That Contribute to the Progression of Damage after Severe TBI; Evidence for Increased Oxidative Stress after Severe TBI; Mitochondrial Dysfunction after Severe TBI; Evidence for Increased Levels of Markers of Inflammation after Severe TBI; Evidence for Increased Release of Glutamate after Severe TBI; Role of Matrix Metalloproteinases after Severe TBI; How to Reduce Oxidative Stress, Chronic Inflammation, and Glutamate Release; Differential Response of Nrf2 to ROS Generated during Acute and Chronic Oxidative Stress; Nrf2 in TBI; Studies on Effects of Single Antioxidants after Severe TBI; Effects of Preparation of Multiple Micronutrients in Troops with TBI; Antioxidants Reduce Glutamate Release; Prevention Strategies for Severe TBI; Problems of Using Single Micronutrients after Severe TBI; Rationale for Using Multiple Micronutrients for Reducing the Progression of TBI; Proposed Micronutrients for Primary Prevention of TBI; Toxicity of Ingredients in Proposed Micronutrient Preparation; Proposed Micronutrients for Secondary Prevention in Combination with Standard Therapy; Diet and Lifestyle Recommendations for Severe TBI; Con
• Edition: 1st
• Publisher Details: Boca Raton : CRC Press
• Publication Date: 2014
• Extent: 1 online resource, illustrations
• Subjects: 616.83; Nervous system -- Degeneration; Nervous system -- Diseases -- Treatment; Trace elements in nutrition -- Therapeutic use
• Languages: English
• ISBNs: 9781482210484
• Related ISBNs: 9781482210477
• Notes: Note: Includes bibliographical references and index.; Note: Description based on CIP data; item not viewed.
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.