Response-adaptive designs in clinical trials. (2013)

• Record Type: Book
• Further Information: Note: Atanu Biswas, Anthony C. Atkinson.
• Authors: Biswas, Atanu, 1970-; Atkinson, A. C (Anthony Curtis)
• Contents: Introduction: Stories and Data; Scope and Limits; Two-Treatment Trials with a Binary Response; Equal Randomisation; Adaptive Allocation; Urn Model; Some Motivating Clinical Trials Adaptive Design: Controversies and Progress ; Why Adaptive?; How Adaptive?; Criticism; What Next? Randomised Balanced Sequential Treatment Allocation ; Introduction; Balance with Two Treatments; Designs with Three or More Treatments; Designs with Covariates; The Distribution of Loss and of Bias; Heteroscedastic Models; More about Biased-Coin Designs; Further Reading Response-Adaptive Designs for Binary Responses ; Introduction; Urn Designs; Play-the-Winner Rule; Randomised Play-the-Winner Rule; Generalised Pólya Urn; Success Driven Design (SDD); Failure-Driven Design (FDD); Birth and Death Urn (BDU); Birth and Death Urn with Immigration; Drop-the-Loser Rule; Odds Ratio-Based Adaptive Designs; Delayed Response in the RPW Rule; Prognostic Factors in Urn Designs; Targeting an Allocation Proportion; Adaptive Designs for Categorical Responses; Comparisons and Recommendations Response-Adaptive Designs for Continuous Responses; Motivation; Some Trials with Continuous Responses; Doubly Adaptive Biased-Coin Designs (DBCD); Nonparametric Designs; Adaptive Designs for Survival Data; Link Function-Based Adaptive Design (BB); Multi-Treatment Multivariate Design; DL Rule for Continuous Responses (CDL) Response-Adaptive Designs for Longitudinal Responses; Repeated Responses; Binary Longitudinal Responses (SLPW); Design and Analysis for the PEMF Data; Longitudinal Categorical Responses; Longitudinal Multivariate Ordinal Responses; Models with Covariates; Continuous Longitudinal Responses; Random Number of Responses ; Numerical Illustrations Optimum Biased-Coin Designs with Covariates; Modelling and Design; Biased-Coin DA-Optimum Designs; Numerical Comparisons for Two Treatments; Designs for Three Treatments; Distribution of Loss; Skewed Allocations; Skewed Allocation – Numerical; Heteroscedastic Normal Models; Allocation Rules for Heteroscedastic Models; Generalized Linear Models; Binary Data; Allocation Rules for Binomial Models; Gamma Data; Loss, Power, Variability; Further Reading: Skewed Designs Optimum Response-Adaptive Designs with Covariates ; Introduction; Link-Function-Based Adaptive Design; Adaptive Designs Maximising Utility; Power Comparisons for Four Rules; Redesigning a Trial: Fluoxetine Hydrochloride; Extensions; Further Reading Optimal Response-Adaptive Designs with Constraints ; Optimal Designs Subject to Constraints; Design of Jennison and Turnbull; RSIHR Design; Maximising Power: Neyman Allocation; Other Designs; BM Design; ZR Design; A General Framework: BBZ Design; Two Normal Populations with Unknown Variances; Two-Sample Nonparametric Design; BM Design for More Than Two Treatments; Optimal Designs with More than One Constraint; Designs for Survival Times; Covariates; Implementation; Adaptive Constraints; Back to Chapter 7 Adaptive Design: Further Important Issues; Bayesian Adaptive Designs; Two-Stage Adaptive Design; Group Sequential Adaptive Design; Optimal Design for Binary Longitudinal Responses; Inverse Sampling; Robustness in Adaptive Designs; Missing Data in Response-Adaptive Designs; Asymptotic Results for CARA Designs; How to Bridge Theory and Practice Appendix: Optimum Design Bibliography Index
• Edition: 1st
• Publisher Details: Boca Raton : Chapman & Hall/CRC
• Publication Date: 2013
• Extent: 1 online resource, illustrations
• Subjects: 615.50724; Clinical trials; Clinical trials -- Statistical methods
• Languages: English
• ISBNs: 9781584886945
• Notes: Note: Description based on CIP data: resource not viewed.
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