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Author/Creator de Lange, Elizabeth C.M.

2. Blood‐Based Biomarkers of Quinpirole Pharmacology: Cluster‐Based PK/PD and Metabolomics to Unravel the Underlying Dynamics in Rat Plasma and Brain. (24th January 2019)

Authors:
van den Brink, Willem J.; Hartman, Robin; van den Berg, Dirk‐Jan; Flik, Gunnar; Gonzalez‐Amoros, Belén; Koopman, Nanda; Elassais‐Schaap, Jeroen; van der Graaf, Piet Hein; Hankemeier, Thomas; de Lange, Elizabeth C.M.
Journal:
CPT: pharmacometrics & systems pharmacology
Issue:
Volume 8:Number 2(2019)
Page Start:
107
Record Type:
Journal Article
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Available online (eLD content is only available in our Reading Rooms) ↗

4. LUF7244, an allosteric modulator/activator of Kv11.1 channels, counteracts dofetilide‐induced torsades de pointes arrhythmia in the chronic atrioventricular block dog model. (30th August 2019)

Authors:
Qile, Muge; Beekman, Henriette D.M.; Sprenkeler, David J.; Houtman, Marien J.C.; van Ham, Willem B.; Stary‐Weinzinger, Anna; Beyl, Stanislav; Hering, Steffen; van den Berg, Dirk‐Jan; de Lange, Elizabeth C.M.; Heitman, Laura H.; IJzerman, Ad P.; Vos, Marc A.; van der Heyden, Marcel A.G.
Journal:
British journal of pharmacology
Issue:
Volume 176:Number 19(2019)
Page Start:
3871
Record Type:
Journal Article
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Available online (eLD content is only available in our Reading Rooms) ↗

5. Mechanistic models enable the rational use of in vitro drug-target binding kinetics for better drug effects in patients. (2nd January 2016)

Authors:
de Witte, Wilhelmus EA; Wong, Yin Cheong; Nederpelt, Indira; Heitman, Laura H; Danhof, Meindert; van der Graaf, Piet H; Gilissen, Ron AHJ; de Lange, Elizabeth C.M.
Journal:
Expert opinion on drug discovery
Issue:
Volume 11:Number 1(2016:Jan.)
Page Start:
45
Record Type:
Journal Article
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Available online (eLD content is only available in our Reading Rooms) ↗