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Author/Creator Zhang, Birong

2. Discovery of a C-8 hydroxychromene as a potent degrader of estrogen receptor alpha with improved rat oral exposure over GDC-0927. Issue 16 (15th August 2019)

Authors:
Labadie, Sharada S.; Li, Jun; Blake, Robert A.; Chang, Jae H.; Goodacre, Simon; Hartman, Steven J.; Liang, Weiling; Kiefer, James R.; Kleinheinz, Tracy; Lai, Tommy; Liao, Jiangpeng; Ortwine, Daniel F.; Mody, Vidhi; Ray, Nicholas C.; Roussel, Fabien; Vinogradova, Maia; Yeap, Siew Kuen; Zhang, Biro...
Journal:
Bioorganic & medicinal chemistry letters
Issue:
Volume 29:Issue 16(2019)
Page Start:
2090
Record Type:
Journal Article
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3. Discovery of GNE-502 as an orally bioavailable and potent degrader for estrogen receptor positive breast cancer. (15th October 2021)

Authors:
Zbieg, Jason R.; Liang, Jun; Li, Jun; Blake, Robert A.; Chang, Jae; Friedman, Lori; Goodacre, Simon; Hartman, Steven J.; Rei Ingalla, Ellen; Kiefer, James R.; Kleinheinz, Tracy; Labadie, Sharada; Lai, Tommy; Liao, Jiangpeng; McLean, Nev; Metcalfe, Ciara; Mody, Vidhi; Nannini, Michelle; Ortwine, D...
Journal:
Bioorganic & medicinal chemistry letters
Issue:
Volume 50(2021)
Page Start:
Record Type:
Journal Article
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4. From a novel HTS hit to potent, selective, and orally bioavailable KDM5 inhibitors. Issue 13 (1st July 2017)

Authors:
Liang, Jun; Labadie, Sharada; Zhang, Birong; Ortwine, Daniel F.; Patel, Snahel; Vinogradova, Maia; Kiefer, James R.; Mauer, Till; Gehling, Victor S.; Harmange, Jean-Christophe; Cummings, Richard; Lai, Tommy; Liao, Jiangpeng; Zheng, Xiaoping; Liu, Yichin; Gustafson, Amy; Van der Porten, Erica; Mao...
Journal:
Bioorganic & medicinal chemistry letters
Issue:
Volume 27:Issue 13(2017)
Page Start:
2974
Record Type:
Journal Article
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6. Identification of an imidazopyridine scaffold to generate potent and selective TYK2 inhibitors that demonstrate activity in an in vivo psoriasis model. Issue 18 (15th September 2017)

Authors:
Liang, Jun; Van Abbema, Anne; Balazs, Mercedesz; Barrett, Kathy; Berezhkovsky, Leo; Blair, Wade S.; Chang, Christine; Delarosa, Donnie; DeVoss, Jason; Driscoll, Jim; Eigenbrot, Charles; Goodacre, Simon; Ghilardi, Nico; MacLeod, Calum; Johnson, Adam; Bir Kohli, Pawan; Lai, Yingjie; Lin, Zhonghua; ...
Journal:
Bioorganic & medicinal chemistry letters
Issue:
Volume 27:Issue 18(2017)
Page Start:
4370
Record Type:
Journal Article
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7. Lead optimization of a pyrazolo[1, 5-a]pyrimidin-7(4H)-one scaffold to identify potent, selective and orally bioavailable KDM5 inhibitors suitable for in vivo biological studies. Issue 16 (15th August 2016)

Authors:
Liang, Jun; Zhang, Birong; Labadie, Sharada; Ortwine, Daniel F.; Vinogradova, Maia; Kiefer, James R.; Gehling, Victor S.; Harmange, Jean-Christophe; Cummings, Richard; Lai, Tommy; Liao, Jiangpeng; Zheng, Xiaoping; Liu, Yichin; Gustafson, Amy; Van der Porten, Erica; Mao, Weifeng; Liederer, Bianca ...
Journal:
Bioorganic & medicinal chemistry letters
Issue:
Volume 26:Issue 16(2016)
Page Start:
4036
Record Type:
Journal Article
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8. Metabolic regulation by prostaglandin E2 impairs lung group 2 innate lymphoid cell responses. Issue 3 (14th October 2022)

Authors:
Robb, Calum T.; Zhou, You; Felton, Jennifer M.; Zhang, Birong; Goepp, Marie; Jheeta, Privjyot; Smyth, Danielle J.; Duffin, Rodger; Vermeren, Sonja; Breyer, Richard M.; Narumiya, Shuh; McSorley, Henry J.; Maizels, Rick M.; Schwarze, Jürgen K. J.; Rossi, Adriano G.; Yao, Chengcan
Journal:
Allergy
Issue:
Volume 78:Issue 3(2023)
Page Start:
714
Record Type:
Journal Article
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9. Steric and Electronic Factors Influence Regio‐isomeric Thiazole Formations Between Substituted Benzothioamides and Ethyl Bromopyruvate. (9th December 2013)

Authors:
Liang, Jun; Soucy, Valerie Dorman; Tusi, Vickie; Liu, Yanzhou; Zhang, Birong; Lai, Yingjie; Magnuson, Steve; Zhu, Bingyan; Wang, Fangdao; Gu, Jinghao; Zhang, Qingfen; Wu, Yuan; Deng, Wei; Yang, Wenqian
Journal:
Journal of heterocyclic chemistry
Issue:
Volume 51:Number 4(2014)
Page Start:
1137
Record Type:
Journal Article
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10. Unexpected equivalent potency of a constrained chromene enantiomeric pair rationalized by co-crystal structures in complex with estrogen receptor alpha. Issue 7 (1st April 2019)

Authors:
Zhang, Birong; Kiefer, James R.; Blake, Robert A.; Chang, Jae H.; Hartman, Steven; Ingalla, Ellen Rei; Kleinheinz, Tracy; Mody, Vidhi; Nannini, Michelle; Ortwine, Daniel F.; Ran, Yingqing; Sambrone, Amy; Sampath, Deepak; Vinogradova, Maia; Zhong, Yu; Nwachukwu, Jerome C.; Nettles, Kendall W.; Lai...
Journal:
Bioorganic & medicinal chemistry letters
Issue:
Volume 29:Issue 7(2019)
Page Start:
905
Record Type:
Journal Article
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