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Author/Creator Ward, Lara

1. Design of selective PI3Kα inhibitors starting from a promiscuous pan kinase scaffold. Issue 13 (1st July 2015)

Authors:
Barlaam, Bernard; Cosulich, Sabina; Fitzek, Martina; Green, Stephen; Harris, Craig S.; Hudson, Kevin; Lambert-van der Brempt, Christine; Ouvry, Gilles; Page, Ken; Ruston, Linette; Ward, Lara; Delouvrié, Bénédicte
Journal:
Bioorganic & medicinal chemistry letters
Issue:
Volume 25:Issue 13(2015)
Page Start:
2679
Record Type:
Journal Article
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2. Discovery of 1-(4-(5-(5-amino-6-(5-tert-butyl-1, 3, 4-oxadiazol-2-yl)pyrazin-2-yl)-1-ethyl-1, 2, 4-triazol-3-yl)piperidin-1-yl)-3-hydroxypropan-1-one (AZD8835): A potent and selective inhibitor of PI3Kα and PI3Kδ for the treatment of cancers. Issue 22 (15th November 2015)

Authors:
Barlaam, Bernard; Cosulich, Sabina; Delouvrié, Bénédicte; Ellston, Rebecca; Fitzek, Martina; Germain, Hervé; Green, Stephen; Hancox, Urs; Harris, Craig S.; Hudson, Kevin; Lambert-van der Brempt, Christine; Lebraud, Honorine; Magnien, Françoise; Lamorlette, Maryannick; Le Griffon, Antoine; Morgent...
Journal:
Bioorganic & medicinal chemistry letters
Issue:
Volume 25:Issue 22(2015)
Page Start:
5155
Record Type:
Journal Article
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3. Discovery of a novel aminopyrazine series as selective PI3Kα inhibitors. Issue 13 (1st July 2017)

Authors:
Barlaam, Bernard; Cosulich, Sabina; Fitzek, Martina; Germain, Hervé; Green, Stephen; Hanson, Lyndsey L.; Harris, Craig S.; Hancox, Urs; Hudson, Kevin; Lambert-van der Brempt, Christine; Lamorlette, Maryannick; Magnien, Françoise; Ouvry, Gilles; Page, Ken; Ruston, Linette; Ward, Lara; Delouvrié, B...
Journal:
Bioorganic & medicinal chemistry letters
Issue:
Volume 27:Issue 13(2017)
Page Start:
3030
Record Type:
Journal Article
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4. Discovery of a series of 8-(1-phenylpyrrolidin-2-yl)-6-carboxamide-2-morpholino-4H-chromen-4-one as PI3Kβ/δ inhibitors for the treatment of PTEN-deficient tumours. Issue 9 (1st May 2017)

Authors:
Barlaam, Bernard; Cosulich, Sabina; Degorce, Sébastien; Ellston, Rebecca; Fitzek, Martina; Green, Stephen; Hancox, Urs; Lambert-van der Brempt, Christine; Lohmann, Jean-Jacques; Maudet, Mickaël; Morgentin, Rémy; Plé, Patrick; Ward, Lara; Warin, Nicolas
Journal:
Bioorganic & medicinal chemistry letters
Issue:
Volume 27:Issue 9(2017)
Page Start:
1949
Record Type:
Journal Article
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5. Discovery of a series of 8-(2, 3-dihydro-1, 4-benzoxazin-4-ylmethyl)-2-morpholino-4-oxo-chromene-6-carboxamides as PI3Kβ/δ inhibitors for the treatment of PTEN-deficient tumours. Issue 9 (1st May 2016)

Authors:
Barlaam, Bernard; Cosulich, Sabina; Degorce, Sébastien; Fitzek, Martina; Green, Stephen; Hancox, Urs; Lambert-van der Brempt, Christine; Lohmann, Jean-Jacques; Maudet, Mickaël; Morgentin, Rémy; Péru, Aurélien; Plé, Patrick; Saleh, Twana; Ward, Lara; Warin, Nicolas
Journal:
Bioorganic & medicinal chemistry letters
Issue:
Volume 26:Issue 9(2016)
Page Start:
2318
Record Type:
Journal Article
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Available online (eLD content is only available in our Reading Rooms) ↗