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Author/Creator Tolar, Martin

1. P1‐043: INHIBITION OF AMYLOID OLIGOMER FORMATION BY ENDOGENOUS METABOLITE OF ALZ‐801/TRAMIPROSATE IN THE HUMAN BRAIN: DISCOVERY AND CHARACTERIZATION OF 3‐SPA IN NORMAL SUBJECTS AND ALZHEIMER'S DISEASE PATIENTS. (1st July 2019)

Authors:
Hey, John; Tolar, Martin; Abushakra, Susan; Power, Aidan; Yu, Jeremy; Kocis, Petr; Vyhnalek, Martin; Hort, Jakub
Journal:
Alzheimer's & dementia
Issue:
Volume 15:Supplement 7(2019)Part 4
Page Start:
P249
Record Type:
Journal Article
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Available online (eLD content is only available in our Reading Rooms) ↗

2. [P4–575]: ALZ‐801 MECHANISM OF ACTION: STOICHIOMETRY OF BETA AMYLOID ANTI‐OLIGOMER EFFECT, PK/PD, AND CLINICAL DOSE SELECTION FOR CONFIRMATORY PHASE 3 PROGRAM IN ALZHEIMER's DISEASE. (1st July 2017)

Authors:
Hey, John; Kocis, Petr; Abushakra, Susan; Yu, Jeremy; Power, Aidan; Blennow, Kaj; Tolar, Martin
Journal:
Alzheimer's & dementia
Issue:
Volume 13:Supplement 7S(2017)Part 32
Page Start:
P1573
Record Type:
Journal Article
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Available online (eLD content is only available in our Reading Rooms) ↗

4. P2‐012: Phase 1 Development of ALZ‐801, a Novel Beta Amyloid Anti‐Aggregation Prodrug of Tramiprosate with Improved Drug Properties, Supporting Bridging to The Phase 3 Program. (1st July 2016)

Authors:
Hey, John; Abushakra, Susan; Power, Aidan; Yu, Jeremy; Versavel, Mark; Tolar, Martin
Journal:
Alzheimer's & dementia
Issue:
Volume 12:Supplement 7S(2016)Part 12
Page Start:
P613
Record Type:
Journal Article
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Available online (eLD content is only available in our Reading Rooms) ↗

5. Effects of Oral ALZ‐801, an Amyloid Oligomer Inhibitor, on Plasma Biomarkers in APOE4 Carriers with Early Alzheimer's Disease: Results of Six‐month Interim Analysis from a Phase 2 Biomarker Study. (20th December 2022)

Authors:
Abushakra, Susan; Hey, John; Blennow, Kaj; Scheltens, Philip; Reiman, Eric M.; Hort, Jakub; Sheardova, Katerina; Rutgers, Sterre M.; Prins, Niels D.; Dautzenberg, Paul; Pazdera, Ladislav; Power, Aidan; Tolar, Martin
Journal:
Alzheimer's & dementia
Issue:
Volume 18(2022)Supplement 10
Page Start:
n/a
Record Type:
Journal Article
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Available online (eLD content is only available in our Reading Rooms) ↗

7. [P1–052]: CLINICAL EFFECTS OF TRAMIPROSATE IN APOE4 HOMOZYGOTES WITH MILD TO MODERATE ALZHEIMER'S DISEASE (AD) ARE SUSTAINED OVER 130 WEEKS: RESULTS OF A PHASE 3 EXTENSION STUDY. (1st July 2017)

Authors:
Abushakra, Susan; Sadowsky, Carl H.; Porsteinsson, Anton P.; Gauthier, Serge; Vellas, Bruno; Power, Aidan; Shen, Larry; Wang, Peter; Hey, John; Tolar, Martin
Journal:
Alzheimer's & dementia
Issue:
Volume 13:Supplement 7S(2017)Part 5
Page Start:
P256
Record Type:
Journal Article
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Available online (eLD content is only available in our Reading Rooms) ↗

8. APOE ε4/ε4 homozygotes with early Alzheimer's disease show accelerated hippocampal atrophy and cortical thinning that correlates with cognitive decline. Issue 1 (4th December 2020)

Authors:
Abushakra, Susan; Porsteinsson, Anton P.; Sabbagh, Marwan; Bracoud, Luc; Schaerer, Joel; Power, Aidan; Hey, John A.; Scott, David; Suhy, Joyce; Tolar, Martin
Journal:
Alzheimer's & dementia
Issue:
Volume 6:Issue 1(2020)
Page Start:
n/a
Record Type:
Journal Article
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Available online (eLD content is only available in our Reading Rooms) ↗