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Author/Creator Tokuhara, Hidekazu

1. Discovery of benzimidazole derivatives as orally active renin inhibitors: Optimization of 3, 5-disubstituted piperidine to improve pharmacokinetic profile. Issue 12 (23rd July 2018)

Authors:
Tokuhara, Hidekazu; Imaeda, Yasuhiro; Fukase, Yoshiyuki; Iwanaga, Koichi; Taya, Naohiro; Watanabe, Koji; Kanagawa, Ray; Matsuda, Keisuke; Kajimoto, Yumiko; Kusumoto, Keiji; Kondo, Mitsuyo; Snell, Gyorgy; Behnke, Craig A.; Kuroita, Takanobu
Journal:
Bioorganic & medicinal chemistry
Issue:
Volume 26:Issue 12(2018)
Page Start:
3261
Record Type:
Journal Article
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2. Discovery of orally efficacious RORγt inverse agonists. Part 2: Design, synthesis, and biological evaluation of novel tetrahydroisoquinoline derivatives. Issue 2 (15th January 2018)

Authors:
Kono, Mitsunori; Oda, Tsuneo; Tawada, Michiko; Imada, Takashi; Banno, Yoshihiro; Taya, Naohiro; Kawamoto, Tetsuji; Tokuhara, Hidekazu; Tomata, Yoshihide; Ishii, Naoki; Ochida, Atsuko; Fukase, Yoshiyuki; Yukawa, Tomoya; Fukumoto, Shoji; Watanabe, Hiroyuki; Uga, Keiko; Shibata, Akira; Nakagawa, Hid...
Journal:
Bioorganic & medicinal chemistry
Issue:
Volume 26:Issue 2(2018)
Page Start:
470
Record Type:
Journal Article
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3. Efficient synthesis of tert-butyl 3-cyano-3-cyclopropyl-2-oxopyrrolidine-4-carboxylates: Highly functionalized 2-pyrrolidinone enabling access to novel macrocyclic Tyk2 inhibitors. Issue 5 (1st March 2020)

Authors:
Sasaki, Yusuke; Tokuhara, Hidekazu; Ohba, Yusuke; Okabe, Atsutoshi; Nakayama, Masaharu; Nakagawa, Hideyuki; Skene, Robert; Hoffman, Isaac; Zou, Hua; Yoshida, Masato
Journal:
Bioorganic & medicinal chemistry letters
Issue:
Volume 30:Issue 5(2020)
Page Start:
Record Type:
Journal Article
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