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Author/Creator Seth, Punit P

1. Conjugation of hydrophobic moieties enhances potency of antisense oligonucleotides in the muscle of rodents and non-human primates. Issue 12 (11th May 2019)

Authors:
Østergaard, Michael E; Jackson, Michaela; Low, Audrey; E. Chappell, Alfred; G. Lee, Richard; Peralta, Rachel Q; Yu, Jinghua; Kinberger, Garth A; Dan, Amy; Carty, Rick; Tanowitz, Michael; Anderson, Patrick; Kim, Tae-Won; Fradkin, Linda; Mullick, Adam E; Murray, Sue; Rigo, Frank; Prakash,...
Journal:
Nucleic acids research
Issue:
Volume 47:Issue 12(2019)
Page Start:
6045
Record Type:
Journal Article
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Available online (eLD content is only available in our Reading Rooms) ↗

2. Fatty acid conjugation enhances potency of antisense oligonucleotides in muscle. Issue 12 (25th May 2019)

Authors:
Prakash, Thazha P; Mullick, Adam E; Lee, Richard G; Yu, Jinghua; Yeh, Steve T; Low, Audrey; Chappell, Alfred E; Østergaard, Michael E; Murray, Sue; Gaus, Hans J; Swayze, Eric E; Seth, Punit P
Journal:
Nucleic acids research
Issue:
Volume 47:Issue 12(2019)
Page Start:
6029
Record Type:
Journal Article
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Available online (eLD content is only available in our Reading Rooms) ↗

3. High-resolution visualization and quantification of nucleic acid–based therapeutics in cells and tissues using Nanoscale secondary ion mass spectrometry (NanoSIMS). Issue 1 (4th December 2020)

Authors:
He, Cuiwen; Migawa, Michael T; Chen, Kai; Weston, Thomas A; Tanowitz, Michael; Song, Wenxin; Guagliardo, Paul; Iyer, K Swaminathan; Bennett, C Frank; Fong, Loren G; Seth, Punit P; Young, Stephen G; Jiang, Haibo
Journal:
Nucleic acids research
Issue:
Volume 49:Issue 1(2021)
Page Start:
1
Record Type:
Journal Article
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5. Site-specific replacement of phosphorothioate with alkyl phosphonate linkages enhances the therapeutic profile of gapmer ASOs by modulating interactions with cellular proteins. Issue 11 (29th April 2019)

Authors:
Migawa, Michael T; Shen, Wen; Wan, W Brad; Vasquez, Guillermo; Oestergaard, Michael E; Low, Audrey; De Hoyos, Cheryl L; Gupta, Ruchi; Murray, Susan; Tanowitz, Michael; Bell, Melanie; Nichols, Joshua G; Gaus, Hans; Liang, Xue-hai; Swayze, Eric E; Crooke, Stanley T; Seth, Punit P
Journal:
Nucleic acids research
Issue:
Volume 47:Issue 11(2019)
Page Start:
5465
Record Type:
Journal Article
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6. Understanding the effect of controlling phosphorothioate chirality in the DNA gap on the potency and safety of gapmer antisense oligonucleotides. Issue 4 (25th January 2020)

Authors:
Østergaard, Michael E; De Hoyos, Cheryl L; Wan, W Brad; Shen, Wen; Low, Audrey; Berdeja, Andres; Vasquez, Guillermo; Murray, Susan; Migawa, Michael T; Liang, Xue-hai; Swayze, Eric E; Crooke, Stanley T; Seth, Punit P
Journal:
Nucleic acids research
Issue:
Volume 48:Issue 4(2020)
Page Start:
1691
Record Type:
Journal Article
View Content:
Available online (eLD content is only available in our Reading Rooms) ↗