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Author/Creator Scearce‐Levie, Kimberly

1. DNL104, a Centrally Penetrant RIPK1 Inhibitor, Inhibits RIP1 Kinase Phosphorylation in a Randomized Phase I Ascending Dose Study in Healthy Volunteers. Issue 2 (25th September 2019)

Authors:
Grievink, Hendrika W.; Heuberger, Jules A.A.C.; Huang, Fen; Chaudhary, Rinkal; Birkhoff, Willem A.J.; Tonn, George R.; Mosesova, Sofia; Erickson, Rebecca; Moerland, Matthijs; Haddick, Patrick C.G.; Scearce‐Levie, Kimberly; Ho, Carole; Groeneveld, Geert Jan
Journal:
Clinical pharmacology & therapeutics
Issue:
Volume 107:Issue 2(2020)
Page Start:
406
Record Type:
Journal Article
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2. Fibrillar Aβ causes profound microglial metabolic perturbations in a novel APP knock‐in mouse model. (1st February 2022)

Authors:
Xia, Dan; Lianoglou, Steve; Sandmann, Thomas; Calvert, Meredith; Suh, Jung; Thomsen, Elliot; Dugas, Jason; Pizzo, Michelle E.; DeVos, Sarah L.; Earr, Timothy K.; Lin, Chia‐Ching; Davis, Sonnet; Ha, Connie; Nguyen, Hoang; Chau, Roni; Yulyaningsih, Ernie; Solanoy, Hilda; Masoud, Shababa T.; Liang, ...
Journal:
Alzheimer's & dementia
Issue:
Volume 17(2021)Supplement 3
Page Start:
n/a
Record Type:
Journal Article
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3. Fibrillar Aβ causes profound microglial metabolic perturbations in a novel APP knock‐in mouse model. (December 2021)

Authors:
Xia, Dan; Lianoglou, Steve; Sandmann, Thomas; Calvert, Meredith; Suh, Jung; Thomsen, Elliot; Dugas, Jason; Pizzo, Michelle E.; DeVos, Sarah L.; Earr, Timothy K.; Lin, Chia‐Ching; Davis, Sonnet; Ha, Connie; Nguyen, Hoang; Chau, Roni; Yulyaningsih, Ernie; Solanoy, Hilda; Masoud, Shababa T.; Liang, ...
Journal:
Alzheimer's & dementia
Issue:
Volume 17(2021)Supplement 3
Page Start:
n/a
Record Type:
Journal Article
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4. Longitudinal biomarkers in amyotrophic lateral sclerosis. Issue 7 (9th June 2020)

Authors:
Huang, Fen; Zhu, Yuda; Hsiao‐Nakamoto, Jennifer; Tang, Xinyan; Dugas, Jason C.; Moscovitch‐Lopatin, Miriam; Glass, Jonathan D.; Brown, Robert H.; Ladha, Shafeeq S.; Lacomis, David; Harris, Jeffrey M.; Scearce‐Levie, Kimberly; Ho, Carole; Bowser, Robert; Berry, James D.
Journal:
Annals of clinical and translational neurology
Issue:
Volume 7:Issue 7(2020)
Page Start:
1103
Record Type:
Journal Article
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5. P1‐359: WIDESPREAD BRAIN DISTRIBUTION AND ROBUST BACE1 INHIBITION FOLLOWING INTRACEREBROVENTRICULAR INFUSION OF ANTI‐BACE1 IN NON‐HUMAN PRIMATES. (1st July 2014)

Authors:
Bumbaca, Daniela; Bumbaca, Daniela; Wildsmith, Kristin; Fuji, Reina; Scearce‐Levie, Kimberly; Maloney, Janice; Meilandt, William; Solanoy, Hilda; Lu, Yanmei; Peng, Kate; Wilson, Blair; Chan, Pamela; Kosky, Andrew; Goo, Marisa; Daugherty, Ann; Couch, Jessica; Keene, Thomas; Hayes, Karen; Nikolas, ...
Journal:
Alzheimer's & dementia
Issue:
Volume 10:Supplement 4S(2014)Part 11
Page Start:
P445
Record Type:
Journal Article
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6. P2–399: Modest reductions in BACE1 activity significantly reduce beta‐amyloid plaque load and neuroinflammation in a mouse model of Alzheimer's disease. (1st July 2013)

Authors:
Meilandt, William; Atwal, Jasvinder; Gadkar, Kapil; Hoyte, Kwame; Luk, Wilman; Lu, Yanmei; Watts, Ryan; Scearce‐Levie, Kimberly
Journal:
Alzheimer's & dementia
Issue:
Volume 9:Supplement 4S(2013)Part 12
Page Start:
P504
Record Type:
Journal Article
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7. Safety, pharmacokinetics and target engagement of novel RIPK1 inhibitor SAR443060 (DNL747) for neurodegenerative disorders: Randomized, placebo‐controlled, double‐blind phase I/Ib studies in healthy subjects and patients. Issue 8 (1st June 2022)

Authors:
Vissers, Maurits F. J. M.; Heuberger, Jules A. A. C.; Groeneveld, Geert Jan; Oude Nijhuis, Jerome; De Deyn, Peter Paul; Hadi, Salah; Harris, Jeffrey; Tsai, Richard M.; Cruz‐Herranz, Andres; Huang, Fen; Tong, Vincent; Erickson, Rebecca; Zhu, Yuda; Scearce‐Levie, Kimberly; Hsiao‐Nakamoto, Jennifer;...
Journal:
Clinical and translational science
Issue:
Volume 15:Issue 8(2022)
Page Start:
2010
Record Type:
Journal Article
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8. Widespread brain distribution and activity following i.c.v. infusion of anti‐β‐secretase (BACE1) in nonhuman primates. (6th October 2017)

Authors:
Yadav, Daniela Bumbaca; Maloney, Janice A; Wildsmith, Kristin R; Fuji, Reina N; Meilandt, William J; Solanoy, Hilda; Lu, Yanmei; Peng, Kun; Wilson, Blair; Chan, Pamela; Gadkar, Kapil; Kosky, Andrew; Goo, Marisa; Daugherty, Ann; Couch, Jessica A; Keene, Thomas; Hayes, Karen; Nikolas, Lisa Jungbaue...
Journal:
British journal of pharmacology
Issue:
Volume 174:Number 22(2017)
Page Start:
4173
Record Type:
Journal Article
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