1. Design of selective PI3Kα inhibitors starting from a promiscuous pan kinase scaffold. Issue 13 (1st July 2015) Authors: Barlaam, Bernard; Cosulich, Sabina; Fitzek, Martina; Green, Stephen; Harris, Craig S.; Hudson, Kevin; Lambert-van der Brempt, Christine; Ouvry, Gilles; Page, Ken; Ruston, Linette; Ward, Lara; Delouvrié, Bénédicte Journal: Bioorganic & medicinal chemistry letters Issue: Volume 25:Issue 13(2015) Page Start: 2679 Record Type: Journal Article View Content: Available online (eLD content is only available in our Reading Rooms) ↗
2. Discovery of 1-(4-(5-(5-amino-6-(5-tert-butyl-1, 3, 4-oxadiazol-2-yl)pyrazin-2-yl)-1-ethyl-1, 2, 4-triazol-3-yl)piperidin-1-yl)-3-hydroxypropan-1-one (AZD8835): A potent and selective inhibitor of PI3Kα and PI3Kδ for the treatment of cancers. Issue 22 (15th November 2015) Authors: Barlaam, Bernard; Cosulich, Sabina; Delouvrié, Bénédicte; Ellston, Rebecca; Fitzek, Martina; Germain, Hervé; Green, Stephen; Hancox, Urs; Harris, Craig S.; Hudson, Kevin; Lambert-van der Brempt, Christine; Lebraud, Honorine; Magnien, Françoise; Lamorlette, Maryannick; Le Griffon, Antoine; Morgent... Journal: Bioorganic & medicinal chemistry letters Issue: Volume 25:Issue 22(2015) Page Start: 5155 Record Type: Journal Article View Content: Available online (eLD content is only available in our Reading Rooms) ↗
3. Discovery of a novel aminopyrazine series as selective PI3Kα inhibitors. Issue 13 (1st July 2017) Authors: Barlaam, Bernard; Cosulich, Sabina; Fitzek, Martina; Germain, Hervé; Green, Stephen; Hanson, Lyndsey L.; Harris, Craig S.; Hancox, Urs; Hudson, Kevin; Lambert-van der Brempt, Christine; Lamorlette, Maryannick; Magnien, Françoise; Ouvry, Gilles; Page, Ken; Ruston, Linette; Ward, Lara; Delouvrié, B... Journal: Bioorganic & medicinal chemistry letters Issue: Volume 27:Issue 13(2017) Page Start: 3030 Record Type: Journal Article View Content: Available online (eLD content is only available in our Reading Rooms) ↗