1. Discovery of a novel tricyclic 4H-thiazolo[5′, 4′:4, 5]pyrano[2, 3-c]pyridine-2-amino scaffold and its application in a PI3Kα inhibitor with high PI3K isoform selectivity and potent cellular activity. Issue 17 (1st September 2015) Authors: Gerspacher, Marc; Fairhurst, Robin A.; Mah, Robert; Roehn-Carnemolla, Esther; Furet, Pascal; Fritsch, Christine; Guthy, Daniel A. Journal: Bioorganic & medicinal chemistry letters Issue: Volume 25:Issue 17(2015) Page Start: 3582 Record Type: Journal Article View Content: Available online (eLD content is only available in our Reading Rooms) ↗
2. Identification and optimisation of 4, 5-dihydrobenzo[1, 2-d:3, 4-d]bisthiazole and 4, 5-dihydrothiazolo[4, 5-h]quinazoline series of selective phosphatidylinositol-3 kinase alpha inhibitors. Issue 17 (1st September 2015) Authors: Fairhurst, Robin A.; Gerspacher, Marc; Imbach-Weese, Patricia; Mah, Robert; Caravatti, Giorgio; Furet, Pascal; Fritsch, Christine; Schnell, Christian; Blanz, Joachim; Blasco, Francesca; Desrayaud, Sandrine; Guthy, Daniel A.; Knapp, Mark; Arz, Dorothee; Wirth, Jasmin; Roehn-Carnemolla, Esther; Luu... Journal: Bioorganic & medicinal chemistry letters Issue: Volume 25:Issue 17(2015) Page Start: 3575 Record Type: Journal Article View Content: Available online (eLD content is only available in our Reading Rooms) ↗