1. Discovery of a C-8 hydroxychromene as a potent degrader of estrogen receptor alpha with improved rat oral exposure over GDC-0927. Issue 16 (15th August 2019) Authors: Labadie, Sharada S.; Li, Jun; Blake, Robert A.; Chang, Jae H.; Goodacre, Simon; Hartman, Steven J.; Liang, Weiling; Kiefer, James R.; Kleinheinz, Tracy; Lai, Tommy; Liao, Jiangpeng; Ortwine, Daniel F.; Mody, Vidhi; Ray, Nicholas C.; Roussel, Fabien; Vinogradova, Maia; Yeap, Siew Kuen; Zhang, Biro... Journal: Bioorganic & medicinal chemistry letters Issue: Volume 29:Issue 16(2019) Page Start: 2090 Record Type: Journal Article View Content: Available online (eLD content is only available in our Reading Rooms) ↗
2. Discovery of a class of highly potent Janus Kinase 1/2 (JAK1/2) inhibitors demonstrating effective cell-based blockade of IL-13 signaling. Issue 12 (15th June 2019) Authors: Zak, Mark; Hanan, Emily J.; Lupardus, Patrick; Brown, David G.; Robinson, Colin; Siu, Michael; Lyssikatos, Joseph P.; Romero, F. Anthony; Zhao, Guiling; Kellar, Terry; Mendonca, Rohan; Ray, Nicholas C.; Goodacre, Simon C.; Crackett, Peter H.; McLean, Neville; Hurley, Christopher A.; Yuen, Po-wai;... Journal: Bioorganic & medicinal chemistry letters Issue: Volume 29:Issue 12(2019) Page Start: 1522 Record Type: Journal Article View Content: Available online (eLD content is only available in our Reading Rooms) ↗