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- ADME absorption, distribution, metabolism and excretion -- Clint intrinsic clearance -- Clp plasma clearance -- Clu unbound clearance -- DCM dichloromethane -- DHEP dog hepatocytes -- DLM dog liver microsomes -- DMAc dimethylacetamide -- DMF dimethylformamide -- DMSO dimethyl sulfoxide -- EP manual electrophysiology -- F bioavailability -- fu fraction unbound -- HHEP human hepatocytes -- HLM human liver microsomes -- IC50 half-maximum inhibitory concentration -- IV intravenous -- lipE lipophilic efficiency -- OATP organic anion-transporting polypeptide -- PEG polyethylene glycol -- PK pharmacokinetics -- ppb plasma protein binding -- PX PatchXpress® electrophysiology -- RHEP rat hepatocytes -- RLM rat liver microsomes -- RRCK Ralph Russ canine kidney cell line -- SAR structure activity relationship -- SNAr nucleophilic aromatic substitution -- T1/2 half-life -- TEA trimethylamine -- TEMPO (2, 2, 6, 6-Tetramethylpiperidin-1-yl)oxyl -- THF tetrahydrofuran -- TPSA topological polar surface area -- Vss apparent volume of distribution at steady state 1
- Acid isostere -- Ion channel -- Pain -- Voltage-gated 1
- Bioorganic chemistry -- Periodicals 1
- Pharmaceutical chemistry -- Periodicals 1