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- Nishigaki, Ryuichi [remove] 1
- 615.19 1
- Ac acetyl -- ADME absorption, distribution, metabolism, and excretion -- aq. aqueous -- AUC total area under the blood concentration–time curve -- bid bis in die (twice per day) -- Boc (tert-butoxy)carbonyl -- Bu butyl -- Bz benzoyl -- cLogP calculate logarithm of the octanolwater partition coefficient -- Cltotal total body clearance -- CPME cyclopentyl methyl ether -- DI desaturation index -- DIPEA N, N-diisopropylethylamine -- DMA N, N-dimethylacetamide -- DMF N, N-dimethylformamide -- DMSO dimethyl sulfoxide -- Et ethyl -- ER endoplasmic reticulum -- Fu unbound fraction -- GI growth inhibition -- HBA hydrogen bond acceptor -- HBD hydrogen bond donor -- IPA 2-propanol -- IPE diisopropyl ether -- LMS liver microsomal stability -- m meta -- Me methyl -- MRT mean residence time -- MW molecular weight -- o ortho -- p para -- PC phosphatidylcholine -- PD pharmacodynamic -- Pd/C palladium on carbon -- PK pharmacokinetic -- PMB p-methoxybenzyl -- Pr propyl -- po per os (oral administration) -- quant. quantitative yield -- rt room temperature -- SAR structureactivity relationship -- sat. saturated aqueous -- SCD stearoyl coenzyme A desaturase -- TEA triethylamine -- tert tertiary -- TFA trifluoroacetic acid -- THF tetrahydrofuran -- Ts tosyl 1
- Biochemistry -- Periodicals 1
- Bioorganic chemistry -- Periodicals 1
- Chemistry, Clinical -- Periodicals 1
- Chemistry, Organic -- Periodicals 1
- Chimie bio-organique -- Périodiques 1
- Chimie pharmaceutique -- Périodiques 1
- Pharmaceutical chemistry -- Periodicals 1
- Stearoyl coenzyme A desaturase 1 -- SCD1 -- 4, 4-Disubstituted piperidine -- Cancer -- Antitumor efficacy -- T-3764518 1