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Author/Creator Marx, Isaac

1. Utilizing structure based drug design and metabolic soft spot identification to optimize the in vitro potency and in vivo pharmacokinetic properties leading to the discovery of novel reversible Bruton's tyrosine kinase inhibitors. (15th August 2021)

Authors:
Hopkins, Brian T.; Bame, Eris; Bell, Noah; Bohnert, Tonika; Bowden-Verhoek, Jon K.; Bui, Minna; Cancilla, Mark T.; Conlon, Patrick; Cullen, Patrick; Erlanson, Daniel A.; Fan, Junfa; Fuchs-Knotts, Tarra; Hansen, Stig; Heumann, Stacey; Jenkins, Tracy J.; Gua, Chuck; Liu, Ying; Liu, YuTing; Lulla, M...
Journal:
Bioorganic & medicinal chemistry
Issue:
Volume 44(2021)
Page Start:
Record Type:
Journal Article
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2. Next‐generation Bruton's tyrosine kinase inhibitor BIIB091 selectively and potently inhibits B cell and Fc receptor signaling and downstream functions in B cells and myeloid cells. Issue 6 (14th June 2021)

Authors:
Bame, Eris; Tang, Hao; Burns, Jeremy C; Arefayene, Million; Michelsen, Klaus; Ma, Bin; Marx, Isaac; Prince, Robin; Roach, Allie M; Poreci, Urjana; Donaldson, Douglas; Cullen, Patrick; Casey, Fergal; Zhu, Jing; Carlile, Thomas M; Sangurdekar, Dipen; Zhang, Baohong; Trapa, Patrick; Santoro, Joseph;...
Journal:
Clinical & translational immunology
Issue:
Volume 10:Issue 6(2021)
Page Start:
n/a
Record Type:
Journal Article
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3. The discovery of benzoxazine sulfonamide inhibitors of NaV1.7: Tools that bridge efficacy and target engagement. Issue 15 (1st August 2017)

Authors:
La, Daniel S.; Peterson, Emily A.; Bode, Christiane; Boezio, Alessandro A.; Bregman, Howard; Chu-Moyer, Margaret Y.; Coats, James; DiMauro, Erin F.; Dineen, Thomas A.; Du, Bingfan; Gao, Hua; Graceffa, Russell; Gunaydin, Hakan; Guzman-Perez, Angel; Fremeau, Robert; Huang, Xin; Ilch, Christopher; K...
Journal:
Bioorganic & medicinal chemistry letters
Issue:
Volume 27:Issue 15(2017)
Page Start:
3477
Record Type:
Journal Article
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4. Development of 2-aminooxazoline 3-azaxanthenes as orally efficacious β-secretase inhibitors for the potential treatment of Alzheimer's disease. Issue 4 (15th February 2015)

Authors:
Chen, Jian Jeffrey; Liu, Qingyian; Yuan, Chester; Gore, Vijay; Lopez, Patricia; Ma, Vu; Amegadzie, Albert; Qian, Wenyuan; Judd, Ted C.; Minatti, Ana E.; Brown, James; Cheng, Yuan; Xue, May; Zhong, Wenge; Dineen, Thomas A.; Epstein, Oleg; Human, Jason; Kreiman, Charles; Marx, Isaac; Weiss, Matthew M.
Journal:
Bioorganic & medicinal chemistry letters
Issue:
Volume 25:Issue 4(2015)
Page Start:
767
Record Type:
Journal Article
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