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Author/Creator Kuwabara, Takashi

1. An iminium ion metabolite hampers the production of the pharmacologically active metabolite of a multikinase inhibitor KW‐2449 in primates: irreversible inhibition of aldehyde oxidase and covalent binding with endogenous proteins. (13th March 2018)

Authors:
Hosogi, Jun; Ohashi, Rui; Maeda, Hiroshi; Fujita, Kazuhiro; Ushiki, Junko; Kuwabara, Takashi; Yamamoto, Yorihiro; Imamura, Toru
Journal:
Biopharmaceutics & drug disposition
Issue:
Volume 39:Number 3(2018:Apr.)
Page Start:
164
Record Type:
Journal Article
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4. Monoamine oxidase B oxidizes a novel multikinase inhibitor KW-2449 to its iminium ion and aldehyde oxidase further converts it to the oxo-piperazine form in human. Issue 5 (October 2017)

Authors:
Hosogi, Jun; Ohashi, Rui; Maeda, Hiroshi; Tashiro, Satoshi; Fuse, Eiichi; Yamamoto, Yorihiro; Kuwabara, Takashi
Journal:
Drug metabolism and pharmacokinetics
Issue:
Volume 32:Issue 5(2017)
Page Start:
255
Record Type:
Journal Article
View Content:
Available online (eLD content is only available in our Reading Rooms) ↗