1. Design and evaluation of 1, 7-naphthyridones as novel KDM5 inhibitors. Issue 18 (15th September 2016) Authors: Labadie, Sharada S.; Dragovich, Peter S.; Cummings, Richard T.; Deshmukh, Gauri; Gustafson, Amy; Han, Ning; Harmange, Jean-Christophe; Kiefer, James R.; Li, Yue; Liang, Jun; Liederer, Bianca M.; Liu, Yichin; Manieri, Wanda; Mao, Wiefeng; Murray, Lesley; Ortwine, Daniel F.; Trojer, Patrick; Vander... Journal: Bioorganic & medicinal chemistry letters Issue: Volume 26:Issue 18(2016) Page Start: 4492 Record Type: Journal Article View Content: Available online (eLD content is only available in our Reading Rooms) ↗
2. Design and evaluation of 1, 7-naphthyridones as novel KDM5 inhibitors. Issue 18 (15th September 2016) Authors: Labadie, Sharada S.; Dragovich, Peter S.; Cummings, Richard T.; Deshmukh, Gauri; Gustafson, Amy; Han, Ning; Harmange, Jean-Christophe; Kiefer, James R.; Li, Yue; Liang, Jun; Liederer, Bianca M.; Liu, Yichin; Manieri, Wanda; Mao, Wiefeng; Murray, Lesley; Ortwine, Daniel F.; Trojer, Patrick; Vander... Journal: Bioorganic & medicinal chemistry letters Issue: Volume 26:Issue 18(2016) Page Start: 4492 Record Type: Journal Article View Content: Available online (eLD content is only available in our Reading Rooms) ↗
3. Discovery of a C-8 hydroxychromene as a potent degrader of estrogen receptor alpha with improved rat oral exposure over GDC-0927. Issue 16 (15th August 2019) Authors: Labadie, Sharada S.; Li, Jun; Blake, Robert A.; Chang, Jae H.; Goodacre, Simon; Hartman, Steven J.; Liang, Weiling; Kiefer, James R.; Kleinheinz, Tracy; Lai, Tommy; Liao, Jiangpeng; Ortwine, Daniel F.; Mody, Vidhi; Ray, Nicholas C.; Roussel, Fabien; Vinogradova, Maia; Yeap, Siew Kuen; Zhang, Biro... Journal: Bioorganic & medicinal chemistry letters Issue: Volume 29:Issue 16(2019) Page Start: 2090 Record Type: Journal Article View Content: Available online (eLD content is only available in our Reading Rooms) ↗
4. Discovery of GNE-502 as an orally bioavailable and potent degrader for estrogen receptor positive breast cancer. (15th October 2021) Authors: Zbieg, Jason R.; Liang, Jun; Li, Jun; Blake, Robert A.; Chang, Jae; Friedman, Lori; Goodacre, Simon; Hartman, Steven J.; Rei Ingalla, Ellen; Kiefer, James R.; Kleinheinz, Tracy; Labadie, Sharada; Lai, Tommy; Liao, Jiangpeng; McLean, Nev; Metcalfe, Ciara; Mody, Vidhi; Nannini, Michelle; Ortwine, D... Journal: Bioorganic & medicinal chemistry letters Issue: Volume 50(2021) Page Start: Record Type: Journal Article View Content: Available online (eLD content is only available in our Reading Rooms) ↗
5. From a novel HTS hit to potent, selective, and orally bioavailable KDM5 inhibitors. Issue 13 (1st July 2017) Authors: Liang, Jun; Labadie, Sharada; Zhang, Birong; Ortwine, Daniel F.; Patel, Snahel; Vinogradova, Maia; Kiefer, James R.; Mauer, Till; Gehling, Victor S.; Harmange, Jean-Christophe; Cummings, Richard; Lai, Tommy; Liao, Jiangpeng; Zheng, Xiaoping; Liu, Yichin; Gustafson, Amy; Van der Porten, Erica; Mao... Journal: Bioorganic & medicinal chemistry letters Issue: Volume 27:Issue 13(2017) Page Start: 2974 Record Type: Journal Article View Content: Available online (eLD content is only available in our Reading Rooms) ↗
6. Inhibition of bromodomain-containing protein 9 for the prevention of epigenetically-defined drug resistance. Issue 15 (1st August 2017) Authors: Crawford, Terry D.; Vartanian, Steffan; Côté, Alexandre; Bellon, Steve; Duplessis, Martin; Flynn, E. Megan; Hewitt, Michael; Huang, Hon-Ren; Kiefer, James R.; Murray, Jeremy; Nasveschuk, Christopher G.; Pardo, Eneida; Romero, F. Anthony; Sandy, Peter; Tang, Yong; Taylor, Alexander M.; Tsui, Vicki... Journal: Bioorganic & medicinal chemistry letters Issue: Volume 27:Issue 15(2017) Page Start: 3534 Record Type: Journal Article View Content: Available online (eLD content is only available in our Reading Rooms) ↗
7. Lead optimization of a pyrazolo[1, 5-a]pyrimidin-7(4H)-one scaffold to identify potent, selective and orally bioavailable KDM5 inhibitors suitable for in vivo biological studies. Issue 16 (15th August 2016) Authors: Liang, Jun; Zhang, Birong; Labadie, Sharada; Ortwine, Daniel F.; Vinogradova, Maia; Kiefer, James R.; Gehling, Victor S.; Harmange, Jean-Christophe; Cummings, Richard; Lai, Tommy; Liao, Jiangpeng; Zheng, Xiaoping; Liu, Yichin; Gustafson, Amy; Van der Porten, Erica; Mao, Weifeng; Liederer, Bianca ... Journal: Bioorganic & medicinal chemistry letters Issue: Volume 26:Issue 16(2016) Page Start: 4036 Record Type: Journal Article View Content: Available online (eLD content is only available in our Reading Rooms) ↗
8. Post-translational regulation of RORγt—A therapeutic target for the modulation of interleukin-17-mediated responses in autoimmune diseases. (August 2016) Authors: Rutz, Sascha; Eidenschenk, Celine; Kiefer, James R.; Ouyang, Wenjun Journal: Cytokine & growth factor reviews Issue: Volume 30(2016) Page Start: 1 Record Type: Journal Article View Content: Available online (eLD content is only available in our Reading Rooms) ↗
9. Target 2035 – update on the quest for a probe for every protein. Issue 1 (3rd December 2021) Authors: Müller, Susanne; Ackloo, Suzanne; Al Chawaf, Arij; Al-Lazikani, Bissan; Antolin, Albert; Baell, Jonathan B.; Beck, Hartmut; Beedie, Shaunna; Betz, Ulrich A. K.; Bezerra, Gustavo Arruda; Brennan, Paul E.; Brown, David; Brown, Peter J.; Bullock, Alex N.; Carter, Adrian J.; Chaikuad, Apirat; Chainea... Journal: RSC medicinal chemistry Issue: Volume 13:Issue 1(2022) Page Start: 13 Record Type: Journal Article View Content: Available online (eLD content is only available in our Reading Rooms) ↗
10. Unexpected equivalent potency of a constrained chromene enantiomeric pair rationalized by co-crystal structures in complex with estrogen receptor alpha. Issue 7 (1st April 2019) Authors: Zhang, Birong; Kiefer, James R.; Blake, Robert A.; Chang, Jae H.; Hartman, Steven; Ingalla, Ellen Rei; Kleinheinz, Tracy; Mody, Vidhi; Nannini, Michelle; Ortwine, Daniel F.; Ran, Yingqing; Sambrone, Amy; Sampath, Deepak; Vinogradova, Maia; Zhong, Yu; Nwachukwu, Jerome C.; Nettles, Kendall W.; Lai... Journal: Bioorganic & medicinal chemistry letters Issue: Volume 29:Issue 7(2019) Page Start: 905 Record Type: Journal Article View Content: Available online (eLD content is only available in our Reading Rooms) ↗