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Author/Creator Hosogi, Jun

1. An iminium ion metabolite hampers the production of the pharmacologically active metabolite of a multikinase inhibitor KW‐2449 in primates: irreversible inhibition of aldehyde oxidase and covalent binding with endogenous proteins. (13th March 2018)

Authors:
Hosogi, Jun; Ohashi, Rui; Maeda, Hiroshi; Fujita, Kazuhiro; Ushiki, Junko; Kuwabara, Takashi; Yamamoto, Yorihiro; Imamura, Toru
Journal:
Biopharmaceutics & drug disposition
Issue:
Volume 39:Number 3(2018:Apr.)
Page Start:
164
Record Type:
Journal Article
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2. Collaborative study using common samples to evaluate the performance of anti-drug antibody assays constructed by different companies. Issue 2 (April 2018)

Authors:
Niimi, Shingo; Nishimiya, Kazuhiro; Nishidate, Masanobu; Saito, Tetsu; Minoura, Kyoko; Kadotsuji, Kenta; Shimakura, Jin; Shigemizu, Hiroko; Hosogi, Jun; Adachi, Maiko; Hashimoto, Tsutomu; Mori, Tamiki; Harada, Hideki; Yamamoto, Ken-ichi; Nakamura, Takahiro; Nomura, Tatsuki; Yamaguchi, Itadaki; So...
Journal:
Drug metabolism and pharmacokinetics
Issue:
Volume 33:Issue 2(2018)
Page Start:
125
Record Type:
Journal Article
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3. Elucidation of the statistical factors that influence anti-drug antibody cut point setting through a multi-laboratory study. (20th March 2019)

Authors:
Nishimura, Kazuko; Shibata, Hiroko; Aoyama, Muneo; Hosogi, Jun; Kadotsuji, Kenta; Minoura, Kyoko; Mori, Tamiki; Nakamura, Takahiro; Nishimiya, Kazuhiro; Nomura, Tatsuki; Saito, Tetsu; Soma, Masako; Wakabayashi, Hiroki; Sakamoto, Norihisa; Niimi, Shingo; Katori, Noriko; Saito, Yoshiro; Ishii-Watab...
Journal:
Bioanalysis
Issue:
Volume 11:Number 6(2019)
Page Start:
509
Record Type:
Journal Article
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5. Japanese bioanalytical method validation guideline: the world's first regulatory guideline dedicated to ligand-binding assays. (May 2015)

Authors:
Imazato-Hirano, Mami; Taniguchi, Yoshitaka; Kakehi, Masaaki; Kuze, Yoji; Nakamura, Takahiro; Minamide, Yoshiyuki; Miya, Kazuhiro; Hosogi, Jun; Katashima, Masataka; Maekawa, Kotaro; Okuda, Haruhiro; Niimi, Shingo; Kawasaki, Nana; Ishii-Watabe, Akiko; Katori, Noriko
Journal:
Bioanalysis
Issue:
Volume 7:Number 9(2015)
Page Start:
1151
Record Type:
Journal Article
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6. Monoamine oxidase B oxidizes a novel multikinase inhibitor KW-2449 to its iminium ion and aldehyde oxidase further converts it to the oxo-piperazine form in human. Issue 5 (October 2017)

Authors:
Hosogi, Jun; Ohashi, Rui; Maeda, Hiroshi; Tashiro, Satoshi; Fuse, Eiichi; Yamamoto, Yorihiro; Kuwabara, Takashi
Journal:
Drug metabolism and pharmacokinetics
Issue:
Volume 32:Issue 5(2017)
Page Start:
255
Record Type:
Journal Article
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Available online (eLD content is only available in our Reading Rooms) ↗