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Author/Creator Higginbottom, Adrian

1. Oligogenic inheritance of optineurin (OPTN) and C9ORF72 mutations in ALS highlights localisation of OPTN in the TDP‐43‐negative inclusions of C9ORF72‐ALS. Issue 2 (24th August 2015)

Authors:
Bury, Joanna J.; Highley, J. Robin; Cooper‐Knock, Johnathan; Goodall, Emily F.; Higginbottom, Adrian; McDermott, Christopher J.; Ince, Paul G.; Shaw, Pamela J.; Kirby, Janine
Journal:
Neuropathology
Issue:
Volume 36:Issue 2(2016:Apr.)
Page Start:
125
Record Type:
Journal Article
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2. Sequestration of multiple RNA recognition motif-containing proteins by C9orf72 repeat expansions. (27th May 2014)

Authors:
Cooper-Knock, Johnathan; Walsh, Matthew J.; Higginbottom, Adrian; Robin Highley, J.; Dickman, Mark J.; Edbauer, Dieter; Ince, Paul G.; Wharton, Stephen B.; Wilson, Stuart A.; Kirby, Janine; Hautbergue, Guillaume M.; Shaw, Pamela J.
Journal:
Brain
Issue:
Volume 137:Part 7(2014:Jul.)
Page Start:
2040
Record Type:
Journal Article
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3. Oligodendrocyte pathology exceeds axonal pathology in white matter in human amyotrophic lateral sclerosis. Issue 3 (8th June 2020)

Authors:
Lorente Pons, Alejandro; Higginbottom, Adrian; Cooper‐Knock, Johnathan; Alrafiah, Aziza; Alofi, Ebtisam; Kirby, Janine; Shaw, Pamela J; Wood, Jonathan D; Highley, J Robin
Journal:
Journal of pathology
Issue:
Volume 251:Issue 3(2020)
Page Start:
262
Record Type:
Journal Article
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4. SPG15 protein deficits are at the crossroads between lysosomal abnormalities, altered lipid metabolism and synaptic dysfunction. Issue 16 (21st March 2022)

Authors:
Marrone, Lara; Marchi, Paolo M; Webster, Christopher P; Marroccella, Raffaele; Coldicott, Ian; Reynolds, Steven; Alves-Cruzeiro, João; Yang, Zih-Liang; Higginbottom, Adrian; Khundadze, Mukhran; Shaw, Pamela J; Hübner, Christian A; Livesey, Matthew R; Azzouz, Mimoun
Journal:
Human molecular genetics
Issue:
Volume 31:Issue 16(2022)
Page Start:
2693
Record Type:
Journal Article
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5. C9ORF72 hexanucleotide repeat exerts toxicity in a stable, inducible motor neuronal cell model, which is rescued by partial depletion of Pten. (1st February 2017)

Authors:
Stopford, Matthew J.; Higginbottom, Adrian; Hautbergue, Guillaume M.; Cooper-Knock, Johnathan; Mulcahy, Padraig J.; De Vos, Kurt J.; Renton, Alan E.; Pliner, Hannah; Calvo, Andrea; Chio, Adriano; Traynor, Bryan J.; Azzouz, Mimoun; Heath, Paul R.; Kirby, Janine; Shaw, Pamela J.
Journal:
Human molecular genetics
Issue:
Volume 26:Number 6(2017:Mar. 15)
Page Start:
1133
Record Type:
Journal Article
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6. AMYOTROPHIC LATERAL SCLEROSIS ASSOCIATED WITH AN INTERMEDIATE LENGTH GGGGCC REPEAT EXPANSION HAS DISTINCT NEUROPATHOLOGY COMPARED TO PATIENTS WITH LARGER EXPANSIONS. Issue 10 (9th September 2014)

Authors:
Beer, Alexander; Cooper-Knock, Johnathan; Higginbottom, Adrian; Robin Highley, J; Wharton, Stephen P; Milano, Antonio; Jones, Ashley; Al-Chalabi, Ammar; Kirby, Janine; Shaw, Pamela J
Journal:
Journal of neurology, neurosurgery and psychiatry
Issue:
Volume 85:Issue 10(2014)
Page Start:
e4
Record Type:
Journal Article
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7. Loss of nuclear TDP‐43 in amyotrophic lateral sclerosis (ALS) causes altered expression of splicing machinery and widespread dysregulation of RNA splicing in motor neurones. Issue 6 (October 2014)

Authors:
Highley, J. Robin; Kirby, Janine; Jansweijer, Joeri A.; Webb, Philip S.; Hewamadduma, Channa A.; Heath, Paul R.; Higginbottom, Adrian; Raman, Rohini; Ferraiuolo, Laura; Cooper‐Knock, Johnathan; McDermott, Christopher J.; Wharton, Stephen B.; Shaw, Pamela J.; Ince, Paul G.
Journal:
Neuropathology & applied neurobiology
Issue:
Volume 40:Issue 6(2014)
Page Start:
670
Record Type:
Journal Article
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8. A neuronal DNA damage response is detected at the earliest stages of Alzheimer's neuropathology and correlates with cognitive impairment in the Medical Research Council's Cognitive Function and Ageing Study ageing brain cohort. (23rd April 2015)

Authors:
Simpson, Julie E.; Ince, Paul G.; Matthews, Fiona E.; Shaw, Pamela J.; Heath, Paul R.; Brayne, Carol; Garwood, Claire; Higginbottom, Adrian; Wharton, Stephen B.; MRC Cognitive Function and Ageing Neuropathology Study Group
Journal:
Neuropathology & applied neurobiology
Issue:
Volume 41:Number 4(2015)
Page Start:
483
Record Type:
Journal Article
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9. Intermediate length C9orf72 expansion in an ALS patient without classical C9orf72 neuropathology. Issue 3 (June 2015)

Authors:
Beer, Alexander M.; Cooper-Knock, Johnathan; Higginbottom, Adrian; Highley, J. Robin; Wharton, Stephen B.; Ince, Paul G.; Milano, Antonio; Jones, Ashley A.; Al-Chalabi, Ammar; Kirby, Janine; Shaw, Pamela J.
Journal:
Amyotrophic lateral sclerosis and frontotemporal degeneration
Issue:
Volume 16:Issue 3/4(2015)
Page Start:
249
Record Type:
Journal Article
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10. The C9orf72 protein interacts with Rab1a and the ULK1 complex to regulate initiation of autophagy. (22nd June 2016)

Authors:
Webster, Christopher P; Smith, Emma F; Bauer, Claudia S; Moller, Annekathrin; Hautbergue, Guillaume M; Ferraiuolo, Laura; Myszczynska, Monika A; Higginbottom, Adrian; Walsh, Matthew J; Whitworth, Alexander J; Kaspar, Brian K; Meyer, Kathrin; Shaw, Pamela J; Grierson, Andrew J; De Vos, Kurt J
Journal:
EMBO journal
Issue:
Volume 35:Number 15(2016)
Page Start:
1656
Record Type:
Journal Article
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