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You searched for: Author/Creator Han, Sungpil- Han, Sungpil [remove] 2
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- A amount of drug in the GI tract (e.g., mg, μmol) -- B/P Blood-to-plasma partition ratio -- Caco-2 human colorectal adenocarcinoma cell -- CP plasma concentration -- CL clearance -- CLh hepatic clearance -- CLint intrinsic clearance -- CYP cytochrome P450 -- Fa fraction absorbed (used as the extent of bioavailability for compartment models) -- Fa_PSA fraction absorbed calculated using PSA -- GI gastrointestinal -- HIM human intestine microsome -- HLM human liver microsome -- i.v. intravenous -- IVIVE In vitro to in vivo extrapolation -- ka first-order absorption rate constant from the GI tract to plasma or blood -- KBF kidney blood flow -- ke first-order elimination rate constant -- ki rate constants of intestinal transit -- Kpi tissue-to-blood partition coefficient -- logD log of the octanol to water distribution coefficient -- logP log of the octanol to water partition coefficient -- MPPGL microsomal protein (mg)/g liver -- PK pharmacokinetics -- PSA polar surface area -- Q inter-compartmental distribution term -- Qh hepatic blood flow -- RSF rat scaling factor -- SAHHEP the surface area of one million hepatocytes -- Vc volume of central compartment -- Vd volume of distribution -- Vp volume of peripheral compartment -- Vss volume of distribution at steady state 1
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