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Author/Creator Gregro, Alison R.

1. Discovery and optimization of a novel series of highly CNS penetrant M4 PAMs based on a 5, 6-dimethyl-4-(piperidin-1-yl)thieno[2, 3-d]pyrimidine core. Issue 13 (1st July 2016)

Authors:
Wood, Michael R.; Noetzel, Meredith J.; Engers, Julie L.; Bollinger, Katrina A.; Melancon, Bruce J.; Tarr, James C.; Han, Changho; West, Mary; Gregro, Alison R.; Lamsal, Atin; Chang, Sichen; Ajmera, Sonia; Smith, Emery; Chase, Peter; Hodder, Peter S.; Bubser, Michael; Jones, Carrie K.; Hopkins, C...
Journal:
Bioorganic & medicinal chemistry letters
Issue:
Volume 26:Issue 13(2016)
Page Start:
3029
Record Type:
Journal Article
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2. Discovery of a novel 3, 4-dimethylcinnoline carboxamide M4 positive allosteric modulator (PAM) chemotype via scaffold hopping. Issue 21 (1st November 2019)

Authors:
Temple, Kayla J.; Engers, Julie L.; Long, Madeline F.; Gregro, Alison R.; Watson, Katherine J.; Chang, Sichen; Jenkins, Matthew T.; Luscombe, Vincent B.; Rodriguez, Alice L.; Niswender, Colleen M.; Bridges, Thomas M.; Conn, P. Jeffrey; Engers, Darren W.; Lindsley, Craig W.
Journal:
Bioorganic & medicinal chemistry letters
Issue:
Volume 29:Issue 21(2019)
Page Start:
Record Type:
Journal Article
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3. Discovery of structurally distinct tricyclic M4 positive allosteric modulator (PAM) chemotypes – Part 2. (1st December 2021)

Authors:
Long, Madeline F.; Capstick, Rory A.; Spearing, Paul K.; Engers, Julie L.; Gregro, Alison R.; Bollinger, Sean R.; Chang, Sichen; Luscombe, Vincent B.; Rodriguez, Alice L.; Cho, Hyekyung P.; Niswender, Colleen M.; Bridges, Thomas M.; Conn, P. Jeffrey; Lindsley, Craig W.; Engers, Darren W.; Temple,...
Journal:
Bioorganic & medicinal chemistry letters
Issue:
Volume 53(2021)
Page Start:
Record Type:
Journal Article
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4. SAR inspired by aldehyde oxidase (AO) metabolism: Discovery of novel, CNS penetrant tricyclic M4 PAMs. Issue 16 (15th August 2019)

Authors:
Chopko, Trevor C.; Han, Changho; Gregro, Alison R.; Engers, Darren W.; Felts, Andrew S.; Poslusney, Mike S.; Bollinger, Katrina A.; Morrison, Ryan D.; Bubser, Michael; Lamsal, Atin; Luscombe, Vincent B.; Cho, Hyekyung P.; Schnetz-Boutaud, Nathalie C.; Rodriguez, Alice L.; Chang, Sichen; Daniels, ...
Journal:
Bioorganic & medicinal chemistry letters
Issue:
Volume 29:Issue 16(2019)
Page Start:
2224
Record Type:
Journal Article
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5. The discovery of VU0652957 (VU2957, Valiglurax): SAR and DMPK challenges en route to an mGlu4 PAM development candidate. Issue 2 (15th January 2019)

Authors:
Panarese, Joseph D.; Engers, Darren W.; Wu, Yong-Jin; Guernon, Jason M.; Chun, Aspen; Gregro, Alison R.; Bender, Aaron M.; Capstick, Rory A.; Wieting, Joshua M.; Bronson, Joanne J.; Macor, John E.; Westphal, Ryan; Soars, Matthew; Engers, Julie E.; Felts, Andrew S.; Rodriguez, Alice L.; Emmitte, K...
Journal:
Bioorganic & medicinal chemistry letters
Issue:
Volume 29:Issue 2(2019)
Page Start:
342
Record Type:
Journal Article
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