1. Conjugation of mono and di-GalNAc sugars enhances the potency of antisense oligonucleotides via ASGR mediated delivery to hepatocytes. Issue 15 (1st August 2016) Authors: Kinberger, Garth A.; Prakash, Thazha P.; Yu, Jinghua; Vasquez, Guillermo; Low, Audrey; Chappell, Alfred; Schmidt, Karsten; Murray, Heather M.; Gaus, Hans; Swayze, Eric E.; Seth, Punit P. Journal: Bioorganic & medicinal chemistry letters Issue: Volume 26:Issue 15(2016) Page Start: 3690 Record Type: Journal Article View Content: Available online (eLD content is only available in our Reading Rooms) ↗
2. Identification of metabolically stable 5΄-phosphate analogs that support single-stranded siRNA activity. Issue 11 (1st May 2017) Authors: Prakash, Thazha P.; Lima, Walt F.; Murray, Heather M.; Li, Wenyu; Kinberger, Garth A.; Chappell, Alfred E.; Gaus, Hans; Seth, Punit P.; Bhat, Balkrishen; Crooke, Stanley T.; Swayze, Eric E. Journal: Nucleic acids research Issue: Volume 45:Issue 11(2017) Page Start: 6994 Record Type: Journal Article View Content: Available online (eLD content is only available in our Reading Rooms) ↗
3. Site-specific replacement of phosphorothioate with alkyl phosphonate linkages enhances the therapeutic profile of gapmer ASOs by modulating interactions with cellular proteins. Issue 11 (29th April 2019) Authors: Migawa, Michael T; Shen, Wen; Wan, W Brad; Vasquez, Guillermo; Oestergaard, Michael E; Low, Audrey; De Hoyos, Cheryl L; Gupta, Ruchi; Murray, Susan; Tanowitz, Michael; Bell, Melanie; Nichols, Joshua G; Gaus, Hans; Liang, Xue-hai; Swayze, Eric E; Crooke, Stanley T; Seth, Punit P Journal: Nucleic acids research Issue: Volume 47:Issue 11(2019) Page Start: 5465 Record Type: Journal Article View Content: Available online (eLD content is only available in our Reading Rooms) ↗
4. Solid-phase synthesis of 5′-triantennary N-acetylgalactosamine conjugated antisense oligonucleotides using phosphoramidite chemistry. Issue 19 (1st October 2015) Authors: Prakash, Thazha P.; Brad Wan, W.; Low, Audrey; Yu, Jinghua; Chappell, Alfred E.; Gaus, Hans; Kinberger, Garth A.; Østergaard, Michael E.; Migawa, Michael T.; Swayze, Eric E.; Seth, Punit P. Journal: Bioorganic & medicinal chemistry letters Issue: Volume 25:Issue 19(2015) Page Start: 4127 Record Type: Journal Article View Content: Available online (eLD content is only available in our Reading Rooms) ↗
5. Solid-phase synthesis of 5′-triantennary N-acetylgalactosamine conjugated antisense oligonucleotides using phosphoramidite chemistry. Issue 19 (1st October 2015) Authors: Prakash, Thazha P.; Brad Wan, W.; Low, Audrey; Yu, Jinghua; Chappell, Alfred E.; Gaus, Hans; Kinberger, Garth A.; Østergaard, Michael E.; Migawa, Michael T.; Swayze, Eric E.; Seth, Punit P. Journal: Bioorganic & medicinal chemistry letters Issue: Volume 25:Issue 19(2015) Page Start: 4127 Record Type: Journal Article View Content: Available online (eLD content is only available in our Reading Rooms) ↗
6. Targeted delivery of antisense oligonucleotides to hepatocytes using triantennary N-acetyl galactosamine improves potency 10-fold in mice. Issue 13 (3rd July 2014) Authors: Prakash, Thazha P.; Graham, Mark J.; Yu, Jinghua; Carty, Rick; Low, Audrey; Chappell, Alfred; Schmidt, Karsten; Zhao, Chenguang; Aghajan, Mariam; Murray, Heather F.; Riney, Stan; Booten, Sheri L.; Murray, Susan F.; Gaus, Hans; Crosby, Jeff; Lima, Walt F.; Guo, Shuling; Monia, Brett P.; Swayze, Er... Journal: Nucleic acids research Issue: Volume 42:Issue 13(2014) Page Start: 8796 Record Type: Journal Article View Content: Available online (eLD content is only available in our Reading Rooms) ↗