1. Activation of IGF1R/p110β/AKT/mTOR confers resistance to α-specific PI3K inhibition. Issue 1 (December 2016) Authors: Leroy, Cedric; Ramos, Pedro; Cornille, Karen; Bonenfant, Debora; Fritsch, Christine; Voshol, Hans; Bentires-Alj, Mohamed Journal: Breast cancer research Issue: Volume 18:Issue 1(2016) Page Start: 1 Record Type: Journal Article View Content: Available online (eLD content is only available in our Reading Rooms) ↗
2. Discovery of a novel tricyclic 4H-thiazolo[5′, 4′:4, 5]pyrano[2, 3-c]pyridine-2-amino scaffold and its application in a PI3Kα inhibitor with high PI3K isoform selectivity and potent cellular activity. Issue 17 (1st September 2015) Authors: Gerspacher, Marc; Fairhurst, Robin A.; Mah, Robert; Roehn-Carnemolla, Esther; Furet, Pascal; Fritsch, Christine; Guthy, Daniel A. Journal: Bioorganic & medicinal chemistry letters Issue: Volume 25:Issue 17(2015) Page Start: 3582 Record Type: Journal Article View Content: Available online (eLD content is only available in our Reading Rooms) ↗
3. Identification and optimisation of 4, 5-dihydrobenzo[1, 2-d:3, 4-d]bisthiazole and 4, 5-dihydrothiazolo[4, 5-h]quinazoline series of selective phosphatidylinositol-3 kinase alpha inhibitors. Issue 17 (1st September 2015) Authors: Fairhurst, Robin A.; Gerspacher, Marc; Imbach-Weese, Patricia; Mah, Robert; Caravatti, Giorgio; Furet, Pascal; Fritsch, Christine; Schnell, Christian; Blanz, Joachim; Blasco, Francesca; Desrayaud, Sandrine; Guthy, Daniel A.; Knapp, Mark; Arz, Dorothee; Wirth, Jasmin; Roehn-Carnemolla, Esther; Luu... Journal: Bioorganic & medicinal chemistry letters Issue: Volume 25:Issue 17(2015) Page Start: 3575 Record Type: Journal Article View Content: Available online (eLD content is only available in our Reading Rooms) ↗
4. Identification and optimisation of a 4′, 5-bisthiazole series of selective phosphatidylinositol-3 kinase alpha inhibitors. Issue 17 (1st September 2015) Authors: Fairhurst, Robin A.; Imbach-Weese, Patricia; Gerspacher, Marc; Caravatti, Giorgio; Furet, Pascal; Zoller, Thomas; Fritsch, Christine; Haasen, Dorothea; Trappe, Joerg; Guthy, Daniel A.; Arz, Dorothee; Wirth, Jasmin Journal: Bioorganic & medicinal chemistry letters Issue: Volume 25:Issue 17(2015) Page Start: 3569 Record Type: Journal Article View Content: Available online (eLD content is only available in our Reading Rooms) ↗
5. Increasing metabolic stability via the deuterium kinetic isotope effect: An example from a proline-amide-urea aminothiazole series of phosphatidylinositol-3 kinase alpha inhibitors. Issue 19 (1st October 2016) Authors: Fairhurst, Robin A.; Caravatti, Giorgio; Guagnano, Vito; Aichholz, Reiner; Blanz, Joachim; Blasco, Francesca; Wipfli, Peter; Fritsch, Christine; Maira, Sauveur-Michel; Schnell, Christian; Seiler, Frank H. Journal: Bioorganic & medicinal chemistry letters Issue: Volume 26:Issue 19(2016) Page Start: 4729 Record Type: Journal Article View Content: Available online (eLD content is only available in our Reading Rooms) ↗