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You searched for: Author/Creator Engers, Julie L.

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1. Discovery and characterization of N-(1, 3-dialkyl-1H-indazol-6-yl)-1H-pyrazolo[4, 3-b]pyridin-3-amine scaffold as mGlu4 positive allosteric modulators that mitigate CYP1A2 induction liability. Issue 15 (15th August 2018)

2. Discovery and optimization of a novel series of highly CNS penetrant M4 PAMs based on a 5, 6-dimethyl-4-(piperidin-1-yl)thieno[2, 3-d]pyrimidine core. Issue 13 (1st July 2016)

3. Discovery of a novel 2, 3-dimethylimidazo[1, 2-a]pyrazine-6-carboxamide M4 positive allosteric modulator (PAM) chemotype. Issue 3 (1st February 2020)

4. Discovery of a novel 2, 4-dimethylquinoline-6-carboxamide M4 positive allosteric modulator (PAM) chemotype via scaffold hopping. Issue 22 (15th November 2017)

5. Discovery of a novel 3, 4-dimethylcinnoline carboxamide M4 positive allosteric modulator (PAM) chemotype via scaffold hopping. Issue 21 (1st November 2019)

6. Discovery of structurally distinct tricyclic M4 positive allosteric modulator (PAM) chemotypes – Part 2. (1st December 2021)

7. Discovery of structurally distinct tricyclic M4 positive allosteric modulator (PAM) chemotypes. Issue 4 (15th February 2020)

8. Mechanisms underlying prelimbic prefrontal cortex mGlu3/mGlu5-dependent plasticity and reversal learning deficits following acute stress. (January 2019)