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Author/Creator Edge, Colin

1. Discovery of 5-substituent-N-arylbenzamide derivatives as potent, selective and orally bioavailable LRRK2 inhibitors. Issue 17 (1st September 2017)

Authors:
Ding, Xiao; Dai, Xuedong; Long, Kai; Peng, Cheng; Andreotti, Daniele; Bamborough, Paul; Eatherton, Andrew J.; Edge, Colin; Jandu, Karamjit S.; Nichols, Paula L.; Philps, Oliver J.; Stasi, Luigi Piero; Wan, Zehong; Xiang, Jia-Ning; Dong, Kelly; Dossang, Pamela; Ho, Ming-Hsun; Li, Yi; Mensah, Lucy;...
Journal:
Bioorganic & medicinal chemistry letters
Issue:
Volume 27:Issue 17(2017)
Page Start:
4034
Record Type:
Journal Article
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2. Discovery of 4-ethoxy-7H-pyrrolo[2, 3-d]pyrimidin-2-amines as potent, selective and orally bioavailable LRRK2 inhibitors. Issue 9 (15th May 2018)

Authors:
Ding, Xiao; Stasi, Luigi Piero; Ho, Ming-Hsun; Zhao, Baowei; Wang, Hailong; Long, Kai; Xu, Qiongfeng; Sang, Yingxia; Sun, Changhui; Hu, Huan; Yu, Haihua; Wan, Zehong; Wang, Lizhen; Edge, Colin; Liu, Qian; Li, Yi; Dong, Kelly; Guan, Xiaoming; Tattersall, F. David; Reith, Alastair D.
Journal:
Bioorganic & medicinal chemistry letters
Issue:
Volume 28:Issue 9(2018)
Page Start:
1615
Record Type:
Journal Article
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4. A High-Throughput Screen to Identify LRRK2 Kinase Inhibitors for the Treatment of Parkinson's Disease Using RapidFire Mass Spectrometry. (February 2016)

Authors:
Leveridge, Melanie; Collier, Lee; Edge, Colin; Hardwicke, Phil; Leavens, Bill; Ratcliffe, Steve; Rees, Mike; Stasi, Luigi Piero; Nadin, Alan; Reith, Alastair D.
Other Names:
Wingfield Jonathan guest-editor.; Wilson Ian D. guest-editor.
Journal:
Journal of biomolecular screening
Issue:
Volume 21:Number 2(2016)
Page Start:
145
Record Type:
Journal Article
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5. 5-Substituted-N-pyridazinylbenzamides as potent and selective LRRK2 inhibitors: Improved brain unbound fraction enables efficacy. Issue 2 (15th January 2019)

Authors:
Ding, Xiao; Stasi, Luigi Piero; Dai, Xuedong; Long, Kai; Peng, Cheng; Zhao, Baowei; Wang, Hailong; Sun, Changhui; Hu, Huan; Wan, Zehong; Jandu, Karamjit S.; Philps, Oliver J.; Chen, Yan; Wang, Lizhen; Liu, Qian; Edge, Colin; Li, Yi; Dong, Kelly; Guan, Xiaoming; Tattersall, F. David
Journal:
Bioorganic & medicinal chemistry letters
Issue:
Volume 29:Issue 2(2019)
Page Start:
212
Record Type:
Journal Article
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Available online (eLD content is only available in our Reading Rooms) ↗