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Author/Creator Chappell, Alfred

1. Conjugation of mono and di-GalNAc sugars enhances the potency of antisense oligonucleotides via ASGR mediated delivery to hepatocytes. Issue 15 (1st August 2016)

Authors:
Kinberger, Garth A.; Prakash, Thazha P.; Yu, Jinghua; Vasquez, Guillermo; Low, Audrey; Chappell, Alfred; Schmidt, Karsten; Murray, Heather M.; Gaus, Hans; Swayze, Eric E.; Seth, Punit P.
Journal:
Bioorganic & medicinal chemistry letters
Issue:
Volume 26:Issue 15(2016)
Page Start:
3690
Record Type:
Journal Article
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Available online (eLD content is only available in our Reading Rooms) ↗

2. Synergistic effect of phosphorothioate, 5′-vinylphosphonate and GalNAc modifications for enhancing activity of synthetic siRNA. Issue 12 (15th June 2016)

Authors:
Prakash, Thazha P.; Kinberger, Garth A.; Murray, Heather M.; Chappell, Alfred; Riney, Stan; Graham, Mark J.; Lima, Walt F.; Swayze, Eric E.; Seth, Punit P.
Journal:
Bioorganic & medicinal chemistry letters
Issue:
Volume 26:Issue 12(2016)
Page Start:
2817
Record Type:
Journal Article
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Available online (eLD content is only available in our Reading Rooms) ↗

3. Targeted delivery of antisense oligonucleotides to hepatocytes using triantennary N-acetyl galactosamine improves potency 10-fold in mice. Issue 13 (3rd July 2014)

Authors:
Prakash, Thazha P.; Graham, Mark J.; Yu, Jinghua; Carty, Rick; Low, Audrey; Chappell, Alfred; Schmidt, Karsten; Zhao, Chenguang; Aghajan, Mariam; Murray, Heather F.; Riney, Stan; Booten, Sheri L.; Murray, Susan F.; Gaus, Hans; Crosby, Jeff; Lima, Walt F.; Guo, Shuling; Monia, Brett P.; Swayze, Er...
Journal:
Nucleic acids research
Issue:
Volume 42:Issue 13(2014)
Page Start:
8796
Record Type:
Journal Article
View Content:
Available online (eLD content is only available in our Reading Rooms) ↗