1. Chimeric siRNAs with chemically modified pentofuranose and hexopyranose nucleotides: altritol-nucleotide (ANA) containing GalNAc–siRNA conjugates: in vitro and in vivo RNAi activity and resistance to 5′-exonuclease. Issue 8 (14th March 2020) Authors: Kumar, Pawan; Degaonkar, Rohan; Guenther, Dale C; Abramov, Mikhail; Schepers, Guy; Capobianco, Marie; Jiang, Yongfeng; Harp, Joel; Kaittanis, Charalambos; Janas, Maja M; Castoreno, Adam; Zlatev, Ivan; Schlegel, Mark K; Herdewijn, Piet; Egli, Martin; Manoharan, Muthiah Journal: Nucleic acids research Issue: Volume 48:Issue 8(2020) Page Start: 4028 Record Type: Journal Article View Content: Available online (eLD content is only available in our Reading Rooms) ↗
2. From bench to bedside: Improving the clinical safety of GalNAc–siRNA conjugates using seed-pairing destabilization. Issue 12 (23rd June 2022) Authors: Schlegel, Mark K; Janas, Maja M; Jiang, Yongfeng; Barry, Joseph D; Davis, Wendell; Agarwal, Saket; Berman, Daniel; Brown, Christopher R; Castoreno, Adam; LeBlanc, Sarah; Liebow, Abigail; Mayo, Tara; Milstein, Stuart; Nguyen, Tuyen; Shulga-Morskaya, Svetlana; Hyde, Sarah; Schofield, Sally; Szeto, ... Journal: Nucleic acids research Issue: Volume 50:Issue 12(2022) Page Start: 6656 Record Type: Journal Article View Content: Available online (eLD content is only available in our Reading Rooms) ↗
3. Overcoming GNA/RNA base-pairing limitations using isonucleotides improves the pharmacodynamic activity of ESC+ GalNAc-siRNAs. Issue 19 (14th October 2021) Authors: Schlegel, Mark K; Matsuda, Shigeo; Brown, Christopher R; Harp, Joel M; Barry, Joseph D; Berman, Daniel; Castoreno, Adam; Schofield, Sally; Szeto, John; Manoharan, Muthiah; Charissé, Klaus; Egli, Martin; Maier, Martin A Journal: Nucleic acids research Issue: Volume 49:Issue 19(2021) Page Start: 10851 Record Type: Journal Article View Content: Available online (eLD content is only available in our Reading Rooms) ↗
4. Small circular interfering RNAs (sciRNAs) as a potent therapeutic platform for gene-silencing. Issue 18 (11th September 2021) Authors: Jahns, Hartmut; Degaonkar, Rohan; Podbevsek, Peter; Gupta, Swati; Bisbe, Anna; Aluri, Krishna; Szeto, John; Kumar, Pawan; LeBlanc, Sarah; Racie, Tim; Brown, Christopher R; Castoreno, Adam; Guenther, Dale C; Jadhav, Vasant; Maier, Martin A; Plavec, Janez; Egli, Martin; Manoharan, Mu... Journal: Nucleic acids research Issue: Volume 49:Issue 18(2021) Page Start: 10250 Record Type: Journal Article View Content: Available online (eLD content is only available in our Reading Rooms) ↗